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Comparative study of ceftriaxone monotherapy versus a combination regimen of cefuroxime plus gentamicin for treatment of serious bacterial infections: the efficacy, safety and effect on fecal flora.

Author: HoepelmanI M, Rozenberg-ArskaM, VerhoefJ

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Ceftriaxone was as effective as a combination of cefuroxime plus gentamicin in treating patients suspected of serious bacterial infections, with a cure rate of 85% for ceftriaxone and 68% for the combination. Ceftriaxone was also more cost-effective and time-saving.
Paper Details　
Original Abstract of the Article :
To assess the efficacy of once daily monotherapy relative to standard combination antibiotic therapy for the initial management of patients suspected of serious bacterial infections, we conducted a randomized trial comparing ceftriaxone (Rocephin) with a combination of cefuroxime plus gentamicin. Of...See full text at original site
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引用元：
https://doi.org/10.1159/000238643

データ提供：米国国立医学図書館（NLM）

Ceftriaxone vs. Cefuroxime Plus Gentamicin: A Head-to-Head Comparison for Serious Infections

The desert of serious bacterial infections can be a dangerous place, requiring swift and effective treatment. This study compares the efficacy and safety of two common antibiotic regimens: ceftriaxone monotherapy and a combination of cefuroxime plus gentamicin. The researchers conducted a randomized trial to assess the effectiveness of these approaches in patients with suspected serious bacterial infections. The results showed that ceftriaxone monotherapy was as effective as the combination regimen, with comparable safety profiles.

Choosing the Right Antibiotic

The study's findings suggest that ceftriaxone monotherapy is an effective and safe alternative to the traditional combination regimen of cefuroxime plus gentamicin for treating serious bacterial infections.

Navigating Antibiotic Treatment

This study emphasizes the importance of selecting the most appropriate antibiotic treatment based on individual patient factors and the specific infection. It's crucial to consult with a healthcare professional to determine the best course of treatment for each individual.

Dr.Camel's Conclusion

This study demonstrates the efficacy and safety of ceftriaxone monotherapy as a viable alternative to combination antibiotic therapy for treating serious bacterial infections. However, it's essential to consult with a healthcare professional to determine the most appropriate treatment based on individual circumstances.

Date :
  1. Date Completed 1989-06-19
  2. Date Revised 2018-02-16
Further Info :

Pubmed ID

3149929

DOI: Digital Object Identifier

10.1159/000238643

Related Literature

Article Analysis
・Side Effects of cefuroxime
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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