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Transcription Factor SOX18 Promotes Clear Cell Renal Cell Carcinoma Progression and Alleviates Cabozantinib-Mediated Inhibitory Effects.
Author: CaipengQin, HuaqiYin, QiangWang, QingLi, ShijunLiu, TaoXu, XiangDai, XiaoweiZhang, XuTang, YiqingDu
Original Abstract of the Article :
The transcription factor SOX18, which was initially discovered as an activator of genetic transcription during embryogenesis, is now implicated in many diseases, including cancer, and is associated with the malignant tumor phenotype, angiogenesis, and lymphangiogenesis. However, the role of SOX18 in...See full text at original site
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引用元:
https://doi.org/10.1158/1535-7163.MCT-19-0043
データ提供:米国国立医学図書館(NLM)
SOX18: A Mastermind in Clear Cell Renal Cell Carcinoma
The field of cancer research is like a vast desert, with researchers constantly searching for the secrets behind tumor growth and progression. This study focuses on the role of SOX18, a transcription factor, in clear cell renal cell carcinoma (ccRCC). The study, using [研究手法], investigated the expression and function of SOX18 in ccRCC. The researchers found that SOX18 [主要な発見], suggesting that it plays a significant role in promoting the malignant phenotype of ccRCC. Additionally, the study reveals that SOX18 can [特筆すべき結果や意義] in response to cabozantinib, a drug used to treat ccRCC. This discovery holds great promise for the development of new treatment strategies targeting SOX18.
SOX18: A New Target for ccRCC Therapy?
The study's findings suggest that SOX18 [社会的な意義]. The ability to target SOX18 could potentially lead to more effective treatments for ccRCC, potentially improving the lives of patients with this challenging disease. This study, like a guiding star in the desert, offers a new direction for researchers to pursue.
SOX18: A Promising Avenue for ccRCC Treatment
This study suggests that SOX18 could be a promising therapeutic target for ccRCC. [健康的なベネフィットもしくはリスク]. Further research is needed to fully understand the role of SOX18 in ccRCC and to develop targeted therapies that effectively inhibit its activity. The study provides a valuable roadmap for future research and development in ccRCC treatment.
Dr.Camel's Conclusion
Understanding the complex interplay between SOX18 and ccRCC is like navigating a desert of intricate pathways. This study unveils the role of SOX18 in promoting tumor growth and its ability to circumvent existing treatments. This discovery paves the way for new therapeutic strategies that target SOX18, offering hope for improved treatment outcomes for patients with ccRCC.
Date :
- Date Completed 2020-07-07
- Date Revised 2020-09-30
Further Info :
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