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Cannabidiol Counteracts the Psychotropic Side-Effects of Δ-9-Tetrahydrocannabinol in the Ventral Hippocampus through Bidirectional Control of ERK1-2 Phosphorylation.

Author: HudsonRoger, LavioletteSteven R, NorrisChristopher, RenardJustine, RushlowWalter J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study demonstrates that THC increases dopamine neuronal activity in the ventral tegmental area, while CBD coadministration reverses this effect by downregulating pERK1-2 signaling. The findings suggest a mechanism by which CBD might counteract the psychotomimetic and psychotropic side effects of THC.
Paper Details　
Original Abstract of the Article :
Evidence suggests that the phytocannabinoids Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) differentially regulate salience attribution and psychiatric risk. The ventral hippocampus (vHipp) relays emotional salience via control of dopamine (DA) neuronal activity states, which are dysregu...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820200/

データ提供：米国国立医学図書館（NLM）

CBD: A Balancing Act in the Brain

We're navigating the intricate world of the brain, specifically focusing on the complex interplay between cannabinoids, the active compounds found in cannabis, and their effects on mood and behavior. This research explores the potential of cannabidiol (CBD), a non-psychoactive cannabinoid, to counteract the psychotropic effects of delta-9-tetrahydrocannabinol (THC), the psychoactive component of cannabis. The researchers meticulously studied the effects of THC and CBD on specific brain regions, focusing on the ventral hippocampus, a key area involved in processing emotions and rewards.

The researchers used a combination of electrophysiology, behavioral analysis, and molecular techniques, carefully examining the effects of THC and CBD on neuronal activity and signaling pathways. They discovered that CBD, like a skilled tightrope walker, delicately balanced the effects of THC, preventing some of its undesirable side effects.

CBD: A Potential Countermeasure to THC's Psychotropic Effects

The study revealed that CBD effectively countered the effects of THC on neuronal activity and behavior, potentially mitigating the psychotomimetic and psychotropic side effects associated with THC.

CBD: A Potential Tool for Managing Cannabis Use

This research offers valuable insights into the potential therapeutic applications of CBD. It suggests that CBD could be a valuable tool for managing the effects of THC, potentially reducing its unwanted side effects and enhancing the therapeutic potential of cannabis-based medications.

Dr.Camel's Conclusion

This research highlights the complex interactions between cannabinoids in the brain, suggesting that CBD might play a vital role in moderating the effects of THC. It's a reminder that understanding these intricate interactions could pave the way for safer and more effective cannabis-based treatments.

Date :
  1. Date Completed 2020-06-29
  2. Date Revised 2020-06-29
Further Info :

Pubmed ID

31570536

DOI: Digital Object Identifier

PMC6820200

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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