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Effect of ceftriaxone on paired-pulse response and long-term potentiation of hippocampal dentate gyrus neurons in rats with Alzheimer-like disease.

Author: AmaniMohammad, HamidiNasrin, NozadAbdollah, SalariAli-Akbar, Sheikhkanloui MilanHamid

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Ceftriaxone, a β-lactam antibiotic, may be beneficial in treating Alzheimer's disease (AD). This study investigates its effects on electrophysiology and behavior in an AD model. Ceftriaxone can potentially reduce glutamate-induced excitotoxicity, which is a key factor in AD.
Paper Details　
Original Abstract of the Article :
Glutamatergic dysfunction is posed as a main stage in neurodegenerative disorders such as Alzheimer's disease (AD). Glutamate-mediated excitotoxicity contributes to cognitive dysfunction and cell death in AD. Ceftriaxone (CFT), a well-known upregulator of GLT-1, selectively induces the expression of...See full text at original site
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引用元：
https://doi.org/10.1016/j.lfs.2019.116969

データ提供：米国国立医学図書館（NLM）

Ceftriaxone: A Potential Oasis in the Desert of Alzheimer's Disease Research

The field of Alzheimer's disease research is a vast and often frustrating desert, with researchers seeking to understand the complex mechanisms of the disease and develop effective treatments. This study explores the potential of ceftriaxone, a well-known antibiotic, as a potential therapeutic agent for Alzheimer's disease. The authors investigated the electrophysiological and behavioral effects of ceftriaxone in an okadaic acid-induced model of Alzheimer's disease, focusing on its ability to modulate glutamate transporter-1 (GLT-1) expression.

Ceftriaxone: A Potential Modulator of Glutamate-Mediated Excitotoxicity

The study found that ceftriaxone exhibited neuroprotective effects in the okadaic acid-induced model of Alzheimer's disease, suggesting its potential to reduce glutamate-mediated excitotoxicity. The findings suggest that ceftriaxone may offer a promising avenue for exploring novel therapeutic approaches to Alzheimer's disease.

Health Implications

This study provides a potential spark of hope in the desert of Alzheimer's disease research, suggesting that ceftriaxone, a commonly used antibiotic, may hold therapeutic potential. Further research is needed to confirm its efficacy and safety in human patients and to explore its long-term effects on cognitive function.

Dr.Camel's Conclusion

This study delves into the complex landscape of Alzheimer's disease research, offering a glimmer of hope in the desert of unanswered questions. The findings suggest that ceftriaxone, a seemingly simple antibiotic, may hold therapeutic potential for Alzheimer's disease. Further research is crucial to fully understand its mechanisms of action and determine its efficacy and safety in human patients.

Date :
  1. Date Completed 2019-12-17
  2. Date Revised 2019-12-17
Further Info :

Pubmed ID

31628912

DOI: Digital Object Identifier

10.1016/j.lfs.2019.116969

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Languages

English

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