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Inhibitory Effects of Probenecid on Pharmacokinetics of Tenofovir Disoproxil Fumarate and Emtricitabine for On-Demand HIV Preexposure Prophylaxis.

Author: AndersonPeter L, BergstromRichard F, BushmanLane R, DestaZeruesenay, GuffordBrandon T, GuptaSamir K, LiuStephanie N, LuJessica Bo Li

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study compared the pharmacokinetic profiles of a single dose of probenecid (PRO)-boosted tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) (test) with the current on-demand HIV preexposure prophylaxis regimen from the IPERGAY study (control). PRO significantly increased the plasma concentrations of tenofovir and emtricitabine. However, the intracellular concentrations of tenofovir-diphosphate were higher at 24 hours but lower at 72 hours in the test group compared to the control.
Paper Details　
Original Abstract of the Article :
In a randomized, crossover pharmacokinetic study in healthy volunteers (N = 14), a single dose of 2 g probenecid (PRO)-boosted 600 mg tenofovir disoproxil fumarate (TDF)/400 mg emtricitabine (FTC) (test (T) +PRO) was compared with the current on-demand HIV preexposure prophy...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/31675437

データ提供：米国国立医学図書館（NLM）

Probenecid: A Potential Boost for On-Demand HIV Preexposure Prophylaxis

The fight against HIV is a continuous journey through a challenging desert landscape. This research explores a potential new strategy to enhance the effectiveness of on-demand HIV preexposure prophylaxis (PrEP). The study investigated the effects of probenecid, a drug known to inhibit the excretion of certain medications, on the pharmacokinetics of tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC), two key components of PrEP. The findings suggest that probenecid could potentially improve the efficacy of on-demand PrEP by increasing the levels of these medications in the body.

Enhancing PrEP's Effectiveness: A New Strategy for Protection

The study demonstrated that probenecid significantly increased the levels of both tenofovir and emtricitabine in the blood. This suggests that probenecid could potentially enhance the protective effects of on-demand PrEP by increasing the duration and effectiveness of these medications. However, further research is needed to confirm these findings and to evaluate the clinical effectiveness of this approach.

Navigating the Desert of HIV: A New Approach to Prevention

This research highlights the ongoing efforts to develop more effective strategies for HIV prevention. The potential of probenecid to enhance on-demand PrEP offers hope for individuals seeking additional protection against HIV infection. However, it's important to note that this approach is still under investigation and should only be used under the guidance of a healthcare professional.

Dr. Camel's Conclusion

This research provides a glimpse into a potential new approach to enhancing the effectiveness of on-demand HIV preexposure prophylaxis. The findings suggest that probenecid could potentially improve the efficacy of PrEP by increasing the levels of key medications in the body. This research highlights the ongoing efforts to develop more effective strategies for HIV prevention, offering hope for a future where HIV transmission is further reduced.

Date :
  1. Date Completed 2021-02-16
  2. Date Revised 2021-05-02
Further Info :

Pubmed ID

31675437

DOI: Digital Object Identifier

NIHMS1645499

Related Literature

Article Analysis
・Effects of probenecid・Effects of emtricitabine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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