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Impact of early antiretroviral treatment on sexual behaviour: a randomised comparison.

Author: , Barbosa de SouzaMonica, BurmanWilliam, CorbelliGiulio M, EmerySean, FriedlandGerald, GatellJose, GerstoftJan, GrulichAndrew, LampeFiona C, MolinaJean Michel, NeatonJames, OrkinChloe, PhillipsAndrew N, RodgerAlison J, RuxrungthamKiat, SadrWafaa El

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Early antiretroviral therapy (ART) did not affect condomless sex with HIV-serodifferent partners among men who have sex with men (MSM), but resulted in a modestly higher prevalence among heterosexuals. However, early ART resulted in a substantial reduction in HIV-transmission-risk sex among both MSM and heterosexuals, to a very low absolute level.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Antiretroviral treatment (ART) reduces HIV infectiousness but the effect of early ART on sexual behaviour is unclear. METHODS: We assessed, within the START randomized trial that enrolled HIV-positive adults with CD4 cell count greater than 500 cells/μl, the effect of early (immediate) ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882545/

データ提供：米国国立医学図書館（NLM）

Early Antiretroviral Treatment and Sexual Behavior: A Tale of Two Groups

In the fight against HIV, antiretroviral treatment (ART) has emerged as a powerful tool. This study focuses on a critical aspect of HIV management: the impact of early ART initiation on sexual behavior. Researchers conducted a randomized trial (START) involving HIV-positive adults with CD4 cell counts above 500 cells/μl, comparing immediate ART initiation with deferred ART. Their findings reveal intriguing insights into the connection between early ART and sexual behavior.

Impact of Early ART: A Mixed Bag of Results

The study, aptly named START, aimed to investigate the relationship between early ART and sexual behavior. The results highlight a nuanced picture. Among men who have sex with men (MSM), there was no significant difference in condomless sex with HIV-serodifferent partners between the immediate and deferred ART groups. However, in heterosexual individuals, a modest increase in condomless sex was observed in the immediate ART group compared to the deferred group, though the difference was more pronounced at 24 months. This suggests that early ART initiation might have a more pronounced effect on sexual behavior in heterosexual individuals compared to MSM.

Navigating the Complexities of Sexual Behavior

This study adds a crucial piece to the puzzle of HIV management. It reminds us that the impact of ART on sexual behavior can be intricate, varying across different populations. Understanding these nuances is essential in guiding patient care and promoting responsible sexual behavior. It's akin to navigating a desert oasis, where diverse ecosystems thrive alongside each other, each with its own unique characteristics.

Dr. Camel's Conclusion

This study sheds light on the complex relationship between early ART initiation and sexual behavior. While the study demonstrates a positive impact of early ART in reducing the risk of HIV transmission, it also highlights the importance of ongoing research to understand the nuances of ART's influence on sexual behavior across different populations. It is a reminder that the fight against HIV requires a multi-faceted approach, encompassing both medical treatment and social support.

Date :
  1. Date Completed 2020-10-09
  2. Date Revised 2021-01-10
Further Info :

Pubmed ID

31764099

DOI: Digital Object Identifier

PMC6882545

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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