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Association between HIV antiretroviral therapy and preterm birth based on antenatal ultrasound gestational age determination: a comparative analysis.
Author: ChiBenjamin H, FairlieLee, FarhadMona, FentonTerry, FowlerMary Glenn, MoodleyDhayendre, NaikShilpa, NakabiitoClemensia, StringerJeffrey S A, VenkateshKartik Kailas
Original Abstract of the Article :
OBJECTIVE: To evaluate the association between HIV antiretroviral therapy (ART) and preterm birth (PTB), when defined by gold standard antenatal ultrasound versus newborn exam. DESIGN: A secondary analysis of the PROMISE 1077BF/1077FF randomized controlled trial, which compared antiretroviral strat...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/31764105
データ提供:米国国立医学図書館(NLM)
HIV Antiretroviral Therapy and Preterm Birth: Exploring the Link
Preterm birth is a major concern in maternal and infant health, and understanding its causes is critical for improving outcomes. This study examines the association between HIV antiretroviral therapy (ART) and preterm birth in pregnant women. The researchers utilized data from a randomized controlled trial (RCT), a gold standard in medical research, to provide robust evidence on the potential link between ART and preterm birth.
HIV Antiretroviral Therapy May Increase Risk of Preterm Birth
The analysis revealed that women receiving HIV ART in pregnancy had a significantly higher risk of preterm birth compared to those who received only zidovudine. This finding suggests that ART may contribute to an increased risk of preterm birth, potentially due to its effects on the uterus or other factors related to pregnancy. The researchers highlighted the need for further investigation to clarify the specific mechanisms involved.
Navigating the Challenges of HIV in Pregnancy
This research highlights the complex interplay between HIV and pregnancy. While ART is crucial for preventing HIV transmission from mother to child, it is important to recognize the potential risks associated with its use. Further research is needed to understand the mechanisms underlying the link between ART and preterm birth and to develop strategies for mitigating these risks. Healthcare providers must carefully weigh the benefits and risks of ART in each individual case, ensuring that the best possible care is provided to both the mother and child.
Dr.Camel's Conclusion
The journey of pregnancy can be challenging, especially for women living with HIV. This research serves as a reminder that there is much we still need to learn about the effects of ART on pregnancy outcomes. However, by understanding the potential risks and benefits of ART, healthcare providers can work to optimize treatment strategies and ensure the best possible outcomes for mothers and their infants. Like a camel navigating the desert, we must carefully assess the potential obstacles and strive to find the most effective path forward.
Date :
- Date Completed 2020-10-09
- Date Revised 2021-03-19
Further Info :
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