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[GABAergic approach of postpartum depression: A translational review of literature].

Author: Bonnet-BrilhaultF, DubertretC, DuriezP, El-HageW, VerbeJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Postpartum depression (PPD) affects 10-15% of mothers after giving birth, impacting their bond with their baby and the health of both mother and child. The causes of PPD may be different from other types of depression. Current treatments focus on managing symptoms, but research is exploring how hormones and the brain's GABA system may be involved in PPD.
Paper Details　
Original Abstract of the Article :
Prevalence of postpartum depression (PPD) ranges from 10 to 15 % of parturients. The impact of the PPD is major on the maternal bond and the health of both mother and child. Its physiopathological mechanisms appear to differ from other types of depression. Today, pharmacotherapy is based on nonspeci...See full text at original site
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引用元：
https://doi.org/10.1016/j.encep.2019.09.007

データ提供：米国国立医学図書館（NLM）

GABAergic Approach to Postpartum Depression

Postpartum depression (PPD) is a common and debilitating condition that affects many new mothers. This review explores the role of the GABAergic system, a neurotransmitter system involved in regulating mood and anxiety, in the development of PPD. The authors review existing research and discuss the potential for targeting the GABAergic system with medications to treat PPD.

Understanding the GABAergic System's Role in PPD

The review suggests that changes in GABAergic neurotransmission may play a role in the development of PPD. The authors point to evidence that neurosteroid levels, which are known to modulate GABA receptors, change during pregnancy and postpartum. These changes could contribute to the development of PPD in some women. The review also highlights the potential for GABAergic medications to be effective in treating PPD.

Health Implications and Lifestyle Considerations

Postpartum depression is a serious condition that can impact both the mother and the child. If you are experiencing symptoms of PPD, it is important to seek help from a healthcare professional. Treatment options may include therapy, medication, or a combination of both. Support groups and peer support can also be helpful for managing PPD.

Dr.Camel's Conclusion

This review offers a promising avenue for understanding and treating postpartum depression. Further research into the role of the GABAergic system in PPD could lead to more effective and targeted treatments for this common and debilitating condition.
Date :
  1. Date Completed 2021-02-01
  2. Date Revised 2021-02-01
Further Info :

Pubmed ID

31767256

DOI: Digital Object Identifier

10.1016/j.encep.2019.09.007

SNS
PICO Info
in preparation
Languages

French

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