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Serum bactericidal activity against aerobes and anaerobes of volunteers receiving cefoxitin or cefotetan.

Author: BonoL, ConciaE, CrucianiM, NavarraA

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Cefotetan showed higher serum bactericidal activity against both aerobic and anaerobic bacteria compared to cefoxitin.
Paper Details　
Original Abstract of the Article :
Six volunteers received intravenously a single 1 g dose of cefoxitin or cefotetan. The 2 groups were crossed after a week of washout. Five strains each of Escherichia coli, Klebsiella pneumoniae, Bacteroides fragilis and Bacteroides thetaiotaomicron susceptible to the administered drugs were tested ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/3180306

データ提供：米国国立医学図書館（NLM）

Evaluating the Bactericidal Activity of Cefoxitin and Cefotetan

[Cefoxitin and cefotetan] are [antibiotics] used to treat [bacterial infections]. This research examines the [bactericidal activity] of these medications against various [aerobic and anaerobic bacteria] in human serum. The authors administered a single dose of either cefoxitin or cefotetan to volunteers and measured [serum bactericidal activity (SBA)] over time. They found that [cefotetan demonstrated superior bactericidal activity against both aerobes and anaerobes compared to cefoxitin].

Cefotetan Shows Superior Bactericidal Activity

The study found that cefotetan exhibited significantly higher SBA against both aerobic and anaerobic bacteria compared to cefoxitin. This suggests that cefotetan may be a more effective treatment option for infections caused by both types of bacteria.

Choosing the Right Antibiotic

Imagine a desert landscape, where different regions might be home to different types of plants and animals. Similarly, the world of bacteria is diverse, with different strains requiring different treatment approaches. This research underscores the importance of choosing the right antibiotic based on the specific type of infection, ensuring optimal treatment outcomes.

Dr.Camel's Conclusion

This study is like a camel caravan exploring a vast and diverse desert landscape of bacteria. It reveals that cefotetan might be a more effective weapon against both aerobic and anaerobic infections compared to cefoxitin. This research emphasizes the importance of choosing the right antibiotic for the right situation, just as a skilled caravan leader chooses the best path for their journey.

Date :
  1. Date Completed 1988-12-15
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

3180306

DOI: Digital Object Identifier

3180306

Related Literature

Article Analysis
・Effects of cefotetan injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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