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Mifepristone Antagonization With Progesterone to Prevent Medical Abortion: A Randomized Controlled Trial.

Author: ChenMelissa J, CreininMitchell D, DaltonLaura, HouMelody Y, StewardRachel

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A clinical trial was halted due to safety concerns when using progesterone to antagonize mifepristone in early pregnancy without subsequent prostaglandin analogue treatment. Patients using only mifepristone may be at high risk of significant hemorrhage.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To estimate the efficacy and safety of mifepristone antagonization with high-dose oral progesterone. METHODS: We planned to enroll 40 patients in a double-blind, placebo-controlled, randomized trial. We enrolled patients at 44-63 days of gestation with ultrasound-confirmed gestational ca...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/31809439

データ提供：米国国立医学図書館（NLM）

Mifepristone Antagonization: A Complex Issue in Medical Abortion

Medical abortion is a safe and effective method for terminating an early pregnancy. Mifepristone, a medication that blocks progesterone, is a key component of medical abortion regimens. This study investigates the efficacy and safety of antagonizing mifepristone with high-dose oral progesterone to prevent medical abortion. The researchers conducted a randomized controlled trial comparing progesterone to placebo in patients planning surgical abortion. The study was prematurely halted due to safety concerns, highlighting the need for further research to understand the potential risks and benefits of mifepristone antagonization.

Mifepristone Antagonization: A Complex and Unsettled Issue

This study explores the complex and unsettled issue of mifepristone antagonization in medical abortion. The researchers encountered safety concerns that led to the premature termination of the study, highlighting the need for further research to understand the potential risks and benefits of this approach.

Navigating Medical Abortion: A Need for Caution and Further Research

Medical abortion is a safe and effective option for terminating an early pregnancy. However, this research highlights the need for further research to understand the potential risks and benefits of mifepristone antagonization. It is essential to consult with a qualified healthcare provider to discuss the risks and benefits of all medical abortion options.

Dr. Camel's Conclusion

This study investigates the efficacy and safety of mifepristone antagonization with high-dose oral progesterone to prevent medical abortion. The study was prematurely halted due to safety concerns, highlighting the need for further research to understand the potential risks and benefits of mifepristone antagonization.

Date :
  1. Date Completed 2020-04-15
  2. Date Revised 2021-01-08
Further Info :

Pubmed ID

31809439

DOI: Digital Object Identifier

00006250-202001000-00021

Related Literature

Article Analysis
・Side Effects of mifepristone (mifeprex)
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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