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Apomorphine sublingual film for off episodes in Parkinson's disease: a randomised, double-blind, placebo-controlled phase 3 study.

Author: , BhargavaParul, BlumDavid, EspayAlberto J, FactorStewart A, HauserRobert A, IsaacsonStuart, LeinonenMika, NaviaBradford, OlanowC Warren, PahwaRajesh, SciarappaKen, ShillHolly A

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This randomized, double-blind, placebo-controlled study found that apomorphine sublingual film provided an efficacious, on-demand treatment for off episodes for most patients with Parkinson's disease. However, nearly a third of patients discontinued treatment primarily because of oropharyngeal side effects.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Many patients with Parkinson's disease have potentially disabling off episodes that are not predictably responsive to levodopa. In this study, we assessed the safety and efficacy of apomorphine sublingual film as an on-demand therapy for off episodes in patients with Parkinson's disease....See full text at original site
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引用元：
https://doi.org/10.1016/S1474-4422(19)30396-5

データ提供：米国国立医学図書館（NLM）

Apomorphine Sublingual Film: A New Hope for Parkinson's Disease Off Episodes

Parkinson's disease can be a debilitating condition, with off episodes causing unpredictable periods of stiffness and difficulty moving. This is like a desert traveler encountering a sandstorm, disrupting their journey. This study investigates the effectiveness of apomorphine sublingual film as an on-demand treatment for off episodes in patients with Parkinson's disease. It's like finding a magical desert potion that can quickly restore mobility and ease movement.

Apomorphine Sublingual Film: A Promising Solution for Off Episodes

The study demonstrates that apomorphine sublingual film is effective in reducing the severity of off episodes, providing patients with a much-needed respite from debilitating symptoms. It's like a desert oasis offering a quick and effective remedy for a sudden sandstorm.

Navigating the Desert of Parkinson's Disease: A Multi-faceted Approach

While apomorphine sublingual film shows promise, the study acknowledges the need for continued research to understand its long-term safety and efficacy. It's like navigating a vast and complex desert, requiring a comprehensive approach to address the many challenges of Parkinson's disease.

Dr.Camel's Conclusion

This research offers a glimmer of hope for those battling the challenges of Parkinson's disease, like a desert oasis appearing on the horizon. Apomorphine sublingual film shows promise as a treatment for off episodes, but further research is needed to ensure its safety and effectiveness. It's a reminder that the journey through Parkinson's disease is complex, requiring ongoing exploration and innovation to find new solutions.

Date :
  1. Date Completed 2020-07-15
  2. Date Revised 2020-11-09
Further Info :

Pubmed ID

31818699

DOI: Digital Object Identifier

10.1016/S1474-4422(19)30396-5

Related Literature

Article Analysis
・Side Effects of apomorphine sublingual
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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