Systematic review and practical guideline for the prevention and management of the renal side effects of lithium therapy.

Author: GrootensKoen P, KerckhoffsAngèle P M, MolmansThomas H J, SchootTessa S

Paper Details 
Original Abstract of the Article :
Lithium is the first line therapy of bipolar mood disorder. Lithium-induced nephrogenic diabetes insipidus (Li-NDI) and lithium nephropathy (Li-NP, i.e., renal insufficiency) are prevalent side effects of lithium therapy, with significant morbidity. The objective of this systematic review is to prov...See full text at original site
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引用元:
https://doi.org/10.1016/j.euroneuro.2019.11.006

データ提供:米国国立医学図書館(NLM)

Navigating the Terrain of Lithium Therapy: A Systematic Review of Renal Side Effects

The treatment of [bipolar mood disorder] often involves a delicate balance between managing symptoms and minimizing potential side effects. This systematic review focuses on the renal side effects associated with [lithium therapy], a mainstay treatment for this condition. The review provides an overview of the evidence regarding the prevention and management of [lithium-induced nephrogenic diabetes insipidus] (Li-NDI) and [lithium nephropathy] (Li-NP), two significant complications of lithium therapy. The authors highlight the importance of early diagnosis, appropriate monitoring, and timely intervention to prevent further progression of these renal complications.

A Comprehensive Approach to Lithium Therapy

The review emphasizes the need for a multifaceted approach to managing lithium therapy, incorporating preventive measures, careful monitoring, and prompt intervention when needed. It recommends strategies such as [once-daily dosing], [targetting the lowest effective serum lithium level], and [preventing lithium intoxication] to minimize the risk of renal side effects. The authors also stress the importance of close collaboration between [psychiatrists], [nephrologists], and [patients] to optimize treatment and ensure early detection of potential complications.

Protecting Renal Health in Bipolar Disorder Management

This review provides valuable guidance for healthcare professionals and patients alike, highlighting the importance of proactive measures to safeguard renal health during [lithium therapy]. It emphasizes the need for [regular monitoring] of renal function, [prompt intervention] for any signs of [Li-NDI] or [Li-NP], and [personalized treatment plans] tailored to individual patient needs and risks. The study serves as a reminder that managing [bipolar mood disorder] requires a holistic approach, considering both mental and physical well-being.

Dr. Camel's Conclusion

Just as a camel must carefully manage its water intake to traverse the desert, we must be mindful of the potential risks associated with lithium therapy. This review provides a valuable guide for navigating the terrain of bipolar disorder treatment, ensuring that we can provide safe and effective care for our patients while protecting their renal health.

Date :
  1. Date Completed 2021-04-22
  2. Date Revised 2021-04-22
Further Info :

Pubmed ID

31837914

DOI: Digital Object Identifier

10.1016/j.euroneuro.2019.11.006

SNS
PICO Info
in preparation
Languages

English

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