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The Risk of QTc-Interval Prolongation in Breast Cancer Patients Treated with Tamoxifen in Combination with Serotonin Reuptake Inhibitors.

Author: BergerFlorine A, BinkhorstLisette, HussaartsKoen G A M, MathijssenRon H J, Mathijssen-van SteinDaniëlle, Oomen-de HoopEsther, de GrootNatasja M S, van AlphenRobbert J, van GelderTeun, van LeeuwenRoelof W F

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates whether there is a drug-drug interaction between tamoxifen and SRIs resulting in a prolonged QTc-interval.
Paper Details　
Original Abstract of the Article :
Antidepressants like the serotonin reuptake inhibitors (SRIs) are often used concomitantly with tamoxifen (e.g. for treatment of depression). This may lead to an additional prolongation of the QTc-interval, with an increased risk of cardiac side effects. Therefore we investigated whether there is a ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914733/

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Drug Interactions: Tamoxifen and SSRIs

This research explores the complex interplay between tamoxifen, a medication often used to treat breast cancer, and serotonin reuptake inhibitors (SSRIs), a class of antidepressants. Like navigating a vast desert landscape, the researchers are cautious of potential dangers, specifically focusing on the risk of QTc-interval prolongation, a potential cardiac side effect. The study aims to shed light on potential drug interactions, offering a safer path through this therapeutic terrain.

A Cautionary Tale of Drug Interactions

This study highlights the potential dangers of drug interactions, like hidden pitfalls in a desert. The researchers found that combining tamoxifen with SSRIs could increase the risk of QTc-interval prolongation, leading to potential cardiac complications. This finding underscores the importance of careful monitoring and communication between healthcare providers and patients.

Avoiding the Sandstorm of Side Effects: Safe Medication Practices

The desert of drug interactions can be a treacherous place. This study underscores the importance of patient safety and the need for thorough understanding of potential side effects. By carefully considering the potential risks and benefits of medication combinations, healthcare professionals can ensure that patients navigate this landscape safely.

Dr. Camel's Conclusion

This study, like a desert guide, offers a word of caution regarding the potential risks of combining tamoxifen with SSRIs. It emphasizes the importance of careful medication management and open communication between patients and healthcare providers. By navigating this landscape with awareness, we can minimize the risk of unintended consequences and ensure the well-being of those seeking medical care.

Date :
  1. Date Completed 2020-01-07
  2. Date Revised 2023-10-20
Further Info :

Pubmed ID

31845095

DOI: Digital Object Identifier

PMC6914733

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