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Sex-Related Differences in Pharmacokinetics and Pharmacodynamics of Frequently Prescribed Drugs: A Review of the Literature.

Author: CzejkaMartin, FarkouhAndré, GottardiRoman, Kautzky-WillerAlexandra, RiedlThomas

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This study reviews the evidence of sex-related differences in drug metabolism, efficacy and safety of frequently prescribed drugs. Clinicians are encouraged to be aware of these differences and adjust dosages accordingly.
Paper Details　
Original Abstract of the Article :
While there is considerable evidence about sex-related differences between men and women in drug metabolism, efficacy and safety of frequently prescribed drugs such as analgesics, tranquillizers, statins and beta-blockers, clinicians' awareness of the implications on dosing and adverse event monitor...See full text at original site
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引用元：
https://doi.org/10.1007/s12325-019-01201-3

データ提供：米国国立医学図書館（NLM）

Sex-Related Differences in Drug Response: A Desert of Variations

This research explores the sex-related differences in the pharmacokinetics and pharmacodynamics of frequently prescribed drugs. It's like discovering that different plants thrive in different parts of a desert, even though they share the same environment. This research examines how sex-specific factors influence drug metabolism, effectiveness, and safety, highlighting the importance of personalized medicine.

Tailoring Treatment to the Desert's Diverse Ecosystems

The research shows that some drugs, such as ibuprofen, work better in men than women, while others, like opioids, are more effective in women. This underscores the need for careful consideration of sex-specific features in drug development and clinical practice. It's like adapting farming techniques to the diverse ecosystems of a desert, ensuring the best results for each specific location.

A Personalized Approach to Medication

This research emphasizes the importance of understanding individual differences when prescribing medications. It calls for more sex-specific considerations in clinical trials and therapeutic guidelines to ensure both efficacy and safety. It's like a skilled desert guide recognizing the unique needs of each traveler, adapting their journey to maximize their chances of success.

Dr.Camel's Conclusion

Understanding the sex-specific differences in drug response is crucial for ensuring safe and effective treatment. It's like recognizing the diverse ecosystems within a desert and tailoring your approach accordingly. This research highlights the importance of personalized medicine and emphasizes the need to consider sex-specific factors in clinical practice.
Date :
  1. Date Completed 2020-09-28
  2. Date Revised 2020-09-28
Further Info :

Pubmed ID

31873866

DOI: Digital Object Identifier

10.1007/s12325-019-01201-3

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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