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The combination of linagliptin, metformin and lifestyle modification to prevent type 2 diabetes (PRELLIM). A randomized clinical trial.

Author: Aguilar-GarcíaAlberto, Angulo-RomeroFabiola, Durán-PérezEdgar G, Evia-ViscarraMaria Lola, Farfán-VázquezDiana, FolliFranco, Guardado-MendozaRodolfo, Jiménez-CejaLilia M, Martínez-LópezYoscelina Estrella, Montes de Oca-LoyolaMaría Luisa, Salazar-LópezSara Stephania, Suárez-PérezErick L, Álvarez-CanalesMildred

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the effect of lingaliptin + metformin + lifestyle on glucose tolerance, pancreatic β-cell function, and type 2 diabetes (T2D) incidence in patients with prediabetes.
Paper Details　
Original Abstract of the Article :
Prediabetes is a highly prevalent health problem with a high risk of complications and progression to type 2 diabetes (T2D). The goals of this study were to evaluate the effect of the combination of lingaliptin + metformin + lifestyle on glucose tolerance, pancreatic β-cell function and T2D incidenc...See full text at original site
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引用元：
https://doi.org/10.1016/j.metabol.2019.154054

データ提供：米国国立医学図書館（NLM）

Preventing Type 2 Diabetes: A Multifaceted Approach with Linagliptin, Metformin, and Lifestyle Modification

The increasing prevalence of type 2 diabetes, like a creeping desert sandstorm, poses a significant threat to global health. This study investigates a multifaceted approach to preventing type 2 diabetes in individuals with prediabetes, combining the medications linagliptin and metformin with lifestyle modifications. The researchers aimed to assess the impact of this combined intervention on glucose tolerance, pancreatic beta-cell function, and the incidence of type 2 diabetes.

A Multifaceted Approach to Diabetes Prevention

The study highlights the importance of a comprehensive approach to diabetes prevention, combining medication and lifestyle modifications. This multifaceted strategy addresses multiple aspects of the disease, potentially increasing its effectiveness in delaying or preventing the onset of type 2 diabetes. The researchers found that the combination of linagliptin, metformin, and lifestyle changes significantly improved glucose tolerance and pancreatic beta-cell function, demonstrating its potential in diabetes prevention.

Lifestyle Modifications: A Crucial Component of Diabetes Prevention

The study underscores the essential role of lifestyle modifications in diabetes prevention. By incorporating healthy dietary choices, regular physical activity, and weight management strategies, individuals can significantly reduce their risk of developing type 2 diabetes. The researchers found that lifestyle modifications, in conjunction with medication, played a crucial role in achieving the desired outcomes.

Dr.Camel's Conclusion

This research, like a guiding oasis in the desert, offers a promising strategy for preventing type 2 diabetes. The combination of linagliptin, metformin, and lifestyle modifications provides a comprehensive approach to managing prediabetes and reducing the risk of developing type 2 diabetes. By adopting a proactive approach to health, we can navigate the desert of diabetes with more confidence and resilience.

Date :
  1. Date Completed 2020-04-20
  2. Date Revised 2020-04-20
Further Info :

Pubmed ID

31887309

DOI: Digital Object Identifier

10.1016/j.metabol.2019.154054

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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