Effects of 0.02% netarsudil ophthalmic solution on intraocular pressure of normotensive dogs.

Author: KeysDeborah A, La CroixNoelle C, MillerPaul E, YangVanessa Y

Paper Details 
Original Abstract of the Article :
OBJECTIVES: To evaluate the effect of QD or BID 0.02% netarsudil ophthalmic solution (Aerie Pharmaceuticals) on intraocular pressure (IOP) in normotensive dogs and to describe any adverse effects. ANIMALS STUDIED: Normotensive Labrador retriever dogs were included in this study: 10 received netarsu...See full text at original site
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引用元:
https://doi.org/10.1111/vop.12736

データ提供:米国国立医学図書館(NLM)

Netarsudil: A Journey Through the Desert of Intraocular Pressure

Imagine a vast desert landscape where the delicate balance of intraocular pressure (IOP) is constantly at risk. This is the terrain that researchers must navigate when seeking treatments for glaucoma, a condition that can lead to blindness. This study explores the potential of netarsudil, a novel ophthalmic solution, to regulate IOP in normotensive dogs, a model system that allows researchers to safely investigate the effects of this drug.

The authors carefully assess the effects of netarsudil, administered both once and twice daily, on IOP in these dogs. They meticulously track the changes in IOP over time, seeking to understand the drug's impact on this critical parameter. Their findings reveal a small but statistically significant IOP reduction with twice-daily dosing, like a subtle shift in the desert sands that can have a profound impact on the overall landscape.

A Shifting Landscape: Exploring the Potential of Netarsudil

The study's findings, while modest in scale, offer a glimpse into the potential of netarsudil as a treatment for glaucoma. The authors emphasize the need for further research to investigate the drug's efficacy in glaucomatous dogs, a more clinically relevant model system. They also highlight the importance of carefully monitoring for adverse effects, ensuring a safe and effective journey through the desert of IOP regulation.

Dr. Camel's Conclusion

The desert of IOP regulation is a delicate and complex landscape, where even small changes can have significant consequences. This study, like a camel caravan carefully navigating the shifting dunes, provides valuable insights into the potential of netarsudil for regulating IOP. The authors' findings, while still preliminary, offer a glimmer of hope for those struggling with glaucoma, suggesting that this novel drug could potentially offer a new path to better vision.

Date :
  1. Date Completed 2021-09-21
  2. Date Revised 2021-09-21
Further Info :

Pubmed ID

31908139

DOI: Digital Object Identifier

10.1111/vop.12736

Related Literature

SNS
PICO Info
in preparation
Languages

English

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