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Safety and Efficacy of Starting Antiretroviral Therapy in the First Week of Life.

Author: AjibolaGbolahan, BatlangOganne, BennettKara, CapparelliEdmund V, HughesMichael D, Jean-PhilippePatrick, KuritzkesDaniel R, LichterfeldMathias, LockmanShahin, MakhemaJoseph, MaswabiKenneth, MohammedTerence, MoyoSikhulile, SakoiMaureen, ShapiroRoger L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

NVP/ZDV/3TC started in the first week of life was safe and effective for HIV-infected infants, even with trough NVP levels below target. Transient viral increases occurred following transition to LPV/r, but by 12 and 24 weeks, most children achieved and maintained viral suppression.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Early antiretroviral therapy (ART) is recommended for infants with human immunodeficiency virus (HIV) infection. However, few antiretroviral options are available for neonates. METHODS: The Early Infant Treatment Study in Botswana tested HIV-exposed infants within 96 hours of birth, and...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850532/

データ提供：米国国立医学図書館（NLM）

Early Antiretroviral Therapy for HIV-Infected Infants

This study investigates the [efficacy and safety of early antiretroviral therapy (ART)] for infants with human immunodeficiency virus (HIV) infection. The study focuses on the feasibility and effectiveness of initiating ART in the first week of life. This research employed a [clinical trial] to evaluate the impact of early ART initiation on viral suppression and overall health outcomes in HIV-infected infants.

Early ART: A Promising Strategy for HIV-Infected Infants

The study found that initiating ART with nevirapine (NVP), zidovudine (ZDV), and lamivudine (3TC) in the first week of life was safe and effective, even when NVP trough levels were below target. The findings highlight the importance of early ART initiation for achieving viral suppression and improving long-term health outcomes for HIV-infected infants. The study underscores the need for ongoing research to optimize ART regimens and address challenges associated with early ART initiation.

Ensuring Optimal Health for HIV-Infected Infants

This research emphasizes the importance of timely and effective treatment for HIV-infected infants. Early ART initiation is crucial for preventing HIV-related complications and promoting healthy development. Remember, access to quality healthcare and early intervention are critical for improving the lives of children living with HIV.

Dr.Camel's Conclusion

This study highlights the benefits of early ART initiation in HIV-infected infants, offering a promising strategy for achieving viral suppression and improving long-term health outcomes. The findings underscore the importance of timely and effective intervention to ensure optimal health for children living with HIV.

Date :
  1. Date Completed 2021-04-28
  2. Date Revised 2022-09-28
Further Info :

Pubmed ID

31927562

DOI: Digital Object Identifier

PMC7850532

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Languages

English

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