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Evaluation of PLGA microspheres with triple regimen on long-term survival of vascularized composite allograft - an experimental study.

Author: ChenJingting, SunBinbin, WangShoubao, WangYinmin, XiongYao, YangJun

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study evaluated a new approach for long-term immunosuppression in vascularized composite allotransplantation (VCA). FK506/MMF/prednisolone (PDNN) was loaded into PLGA microspheres (PLGA MS) and administered as a single injection, significantly prolonging allograft survival compared to oral treatment. This method could offer a promising approach for long-term prevention of immune rejection in VCA.
Paper Details　
Original Abstract of the Article :
Systemic immunosuppression is indispensable for vascularized composite allotransplantation (VCA). Daily administration of standard triple therapy regimen of tacrolimus (FK506), mycophenolate mofetil (MMF), and steroid has severe side effects and reduces the compliance of VCA recipients. To overcome ...See full text at original site
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引用元：
https://doi.org/10.1111/tri.13574

データ提供：米国国立医学図書館（NLM）

PLGA Microspheres for Prolonged Immunosuppression

[Vascularized composite allograft (VCA)] transplantation is a complex and challenging procedure, requiring [systemic immunosuppression] to prevent [rejection]. This study investigates the potential of [PLGA microspheres] loaded with a [triple regimen] of immunosuppressants for [prolonged immunosuppression] in [VCA recipients]. The research utilizes a [rat hind limb transplantation model] to assess the [efficacy and safety] of this approach.

PLGA Microspheres: A Promising Solution for Immunosuppression?

The results indicate that [PLGA microspheres] may offer a [novel and effective] method for [prolonged immunosuppression] in [VCA recipients]. The study found that a [single injection] of [FK506/MMF/PDNN-PLGA MS] significantly [prolonged allograft survival] compared to [oral administration] of the same medications.

VCA Transplantation: A New Frontier in Medicine

The findings suggest that [PLGA microspheres] could revolutionize [immunosuppression] in [VCA transplantation]. This research opens up exciting possibilities for [reducing the frequency of medication administration], [minimizing side effects], and improving [patient compliance]. It's like a camel caravan discovering a new source of water in a remote desert – a breakthrough that can change the course of a journey.

Dr. Camel's Conclusion

This research on PLGA microspheres for VCA transplantation is like a camel caravan discovering a hidden oasis in a vast and arid landscape. The findings suggest a potential breakthrough in immunosuppression, offering a more convenient and effective approach for patients. This is a promising journey, but as a camel who values both innovation and caution, I urge continued research and clinical trials to ensure safety and efficacy.
Date :
  1. Date Completed 2021-06-24
  2. Date Revised 2021-06-24
Further Info :

Pubmed ID

31930539

DOI: Digital Object Identifier

10.1111/tri.13574

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Article Analysis
・Side Effects of mycophenolate injection
SNS
PICO Info
in preparation
Languages

English

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