Paper Details

  1. Home
  2. Paper Details

PPARγ-Independent Side Effects of Thiazolidinediones on Mitochondrial Redox State in Rat Isolated Hearts.

Author: CamaraAmadou K S, ElorbanyReem, RiessMatthias L, StoweDavid F, WeihrauchDorothee

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of thiazolidinediones (TZDs), a class of anti-diabetic drugs, on myocardial and mitochondrial function in isolated rat hearts. The study found that rosiglitazone administration before ischemia-reperfusion (IR) increased IR injury. Both rosiglitazone and pioglitazone caused excessive mitochondrial uncoupling, suggesting that TZDs may enhance myocardial IR injury through mitochondrial dysfunction.
Paper Details　
Original Abstract of the Article :
The effect of anti-diabetic thiazolidinediones (TZDs) on contributing to heart failure and cardiac ischemia/reperfusion (IR) injury is controversial. In this study we investigated the effect of select TZDs on myocardial and mitochondrial function in Brown Norway rat isolated hearts. In a first set o...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017211/

データ提供：米国国立医学図書館（NLM）

Thiazolidinediones: A Complex Relationship with Heart Health

Thiazolidinediones (TZDs) are a class of drugs commonly used for treating type 2 diabetes. This study investigates the effects of TZDs on the heart, specifically focusing on their impact on mitochondrial function. Researchers used isolated rat hearts to study the effects of two TZDs, rosiglitazone and pioglitazone, on mitochondrial redox state.

Mitochondrial Mishaps: TZDs and Heart Health

The study revealed that TZDs can lead to excessive mitochondrial uncoupling, a process that can disrupt the balance of energy production in the heart. This effect was independent of the PPARγ pathway, the primary target of TZDs in diabetes treatment. Moreover, the study found that acute rosiglitazone administration before ischemia-reperfusion injury, a type of heart damage, was associated with increased injury in isolated rat hearts. This finding raises concerns about the potential cardiotoxicity of TZDs, particularly in situations of heart stress.

Heart Health Considerations: Navigating the Desert of Diabetes

This study underscores the complex relationship between TZDs and heart health. It's like navigating a vast desert; while TZDs can be beneficial for managing diabetes, they may also have unintended consequences for the heart. This research emphasizes the need for careful monitoring and consideration of potential risks associated with TZD therapy, particularly in patients with underlying heart conditions or at risk for heart disease.

Dr. Camel's Conclusion

This study highlights the potential downsides of TZDs for heart health. It's like a mirage in the desert; while TZDs can appear beneficial for diabetes management, they might also have hidden risks for the heart. This research emphasizes the importance of careful monitoring and personalized treatment plans when using TZDs, ensuring patient safety and well-being.

Date :
  1. Date Completed 2021-01-06
  2. Date Revised 2021-01-06
Further Info :

Pubmed ID

31968546

DOI: Digital Object Identifier

PMC7017211

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.