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Diarrhoeal events can trigger long-term Clostridium difficile colonization with recurrent blooms.

Author: ElsherbiniJoseph A, ErdmanSusan, PolzMartin F, PoutahidisTheofilos, VanInsbergheDavid, VarianBernard

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the relationship between gastrointestinal disturbances and Clostridium difficile colonization. It found that diarrheal events trigger susceptibility to C. difficile colonization, particularly in the days immediately following acute disturbances. This finding suggests that interrupting transmission during this critical window may help lower the incidence of infection.
Paper Details　
Original Abstract of the Article :
Although Clostridium difficile is widely considered an antibiotic- and hospital-associated pathogen, recent evidence indicates that this is an insufficient depiction of the risks and reservoirs. A common thread that links all major risk factors of infection is their association with gastrointestinal...See full text at original site
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引用元：
https://doi.org/10.1038/s41564-020-0668-2

データ提供：米国国立医学図書館（NLM）

Diarrhoea and Clostridium difficile: A Hidden Connection

Clostridium difficile, a bacterium that can cause severe diarrhoea, is often associated with antibiotic use and hospital settings. However, recent research suggests that this is a limited view of the risks and reservoirs of C. difficile. This study delved deeper into the factors that contribute to C. difficile colonization, focusing on the role of diarrhoeal events.

Diarrhoea Triggers C. difficile Colonization: A New Insight

The study found that diarrhoeal events, even those caused by non-C. difficile infections, can trigger C. difficile colonization. The researchers detected C. difficile in individuals recovering from food poisoning and Vibrio cholerae infections, suggesting that any disturbance to the gut microbiome can increase susceptibility to C. difficile. They observed that C. difficile colonization could persist for extended periods, with variable patterns of abundance, highlighting the potential for long-term carriage and recurrent blooms. It's like a hidden oasis of C. difficile lurking in the desert of the gut microbiome, ready to bloom after a disturbance.

Preventing C. difficile: A Focus on Gastrointestinal Health

This research emphasizes the importance of maintaining gastrointestinal health to prevent C. difficile colonization. Focusing on a balanced diet, managing stress, and avoiding unnecessary antibiotic use can help minimize the risk of C. difficile infection. It's like safeguarding our gut microbiome, ensuring a healthy balance and preventing the C. difficile oasis from blooming.

Dr. Camel's Conclusion

This study reveals a hidden oasis of C. difficile lurking in the desert of the gut microbiome, highlighting the importance of maintaining gastrointestinal health to prevent colonization. It's like protecting our inner desert landscape, ensuring a healthy balance and preventing the C. difficile oasis from blooming.

Date :
  1. Date Completed 2020-07-16
  2. Date Revised 2021-01-19
Further Info :

Pubmed ID

32042128

DOI: Digital Object Identifier

10.1038/s41564-020-0668-2

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Languages

English

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