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Enhanced transdermal delivery of meloxicam by nanocrystals: Preparation, <i>in vitro</i> and <i>in vivo</i> evaluation.

Author: ChenZhongjian, LiYe, LuYi, WuWei, WuXiying, YuQin, ZhuQuangang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study developed a nanocrystal formulation to enhance the transdermal delivery of meloxicam (MLX), an efficient pain and inflammatory symptom reliever. The MLX nanocrystals were successfully prepared by the nanoprecipitation technique, resulting in enhanced apparent solubility, dissolution, and hair follicular penetration, leading to a high and prolonged plasma MLX concentration.
Paper Details　
Original Abstract of the Article :
Meloxicam (MLX) is efficient in relieving pain and inflammatory symptoms, which, however, is limited by the poor solubility and gastrointestinal side effects. The objective of this study is to develop a nanocrystal formulation to enhance transdermal delivery of MLX. MLX nanocrystals were successfull...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7032118/

データ提供：米国国立医学図書館（NLM）

Meloxicam Delivery: Crossing the Desert of Skin

Meloxicam, a nonsteroidal anti-inflammatory drug (NSAID), effectively relieves pain and inflammation. However, its poor solubility and gastrointestinal side effects limit its potential. This study explores the potential of nanocrystal formulations for enhancing the transdermal delivery of meloxicam. The researchers sought to create a formulation that could efficiently navigate the challenging terrain of skin, delivering meloxicam directly to the target site, minimizing the risk of gastrointestinal side effects.

Nanocrystals: Navigating the Desert with Ease

The authors successfully prepared nanocrystals of meloxicam using a nanoprecipitation technique. These nanocrystals exhibited enhanced solubility and permeability, allowing for efficient transdermal delivery. This is like a camel caravan equipped with advanced navigational tools, efficiently traversing the vast and challenging desert landscape. The study found that nanocrystals significantly increased both in vitro and in vivo transdermal penetration of meloxicam compared to traditional formulations.

A New Frontier in Pain Management

This research offers a promising solution for improving meloxicam delivery, potentially revolutionizing pain management. The use of nanocrystals offers a more efficient and targeted approach, minimizing gastrointestinal side effects and enhancing the therapeutic efficacy of this valuable drug. This is like discovering a new route through the desert, allowing for a smoother and more efficient journey.

Dr. Camel's Conclusion

This study explores the potential of nanocrystals for enhancing the transdermal delivery of meloxicam. The findings suggest that nanocrystals offer a promising solution for improving the efficacy and safety of this NSAID. This research represents a significant step forward in pain management, offering a more targeted and efficient approach to delivering pain relief.
Date :
  1. Date Completed n.d.
  2. Date Revised 2020-09-28
Further Info :

Pubmed ID

32104426

DOI: Digital Object Identifier

PMC7032118

Related Literature

Article Analysis
・Side Effects of meloxicam
SNS
PICO Info
in preparation
Languages

English

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