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Treatment of Highly Drug-Resistant Pulmonary Tuberculosis.

Author: , BatesonAnna, ConradieFrancesca, CrookAngela M, DiaconAndreas H, EgiziErica, EverittDaniel, HowellPauline, HuntRobert, LiMengchun, McHughTimothy D, MendelCarl M, MoreiraJoanna, NgubaneNosipho, OlugbosiMorounfolu, SpigelmanMelvin, TimmJuliano, Van NiekerkChristo, WillsGenevieve H

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study found that a combination of bedaquiline, pretomanid, and linezolid led to a favorable outcome in 90% of patients with highly drug-resistant forms of tuberculosis. However, the study also observed some associated toxic effects, including peripheral neuropathy and myelosuppression.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Patients with highly drug-resistant forms of tuberculosis have limited treatment options and historically have had poor outcomes. METHODS: In an open-label, single-group study in which follow-up is ongoing at three South African sites, we investigated treatment with three oral drugs - b...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955640/

データ提供：米国国立医学図書館（NLM）

Treatment of Highly Drug-Resistant Tuberculosis: Finding Oasis in the Desert of Resistance

Tuberculosis, a persistent threat in the desert of infectious diseases, often develops resistance to standard treatments, leaving patients vulnerable. This study investigates the efficacy and safety of a novel drug combination, consisting of bedaquiline, pretomanid, and linezolid, for treating highly drug-resistant forms of tuberculosis. The researchers conducted an open-label, single-group study involving 109 patients with extensively drug-resistant tuberculosis and multidrug-resistant tuberculosis. The results showed a high rate of favorable outcomes at 6 months after the end of treatment, offering a glimmer of hope for patients facing this challenging condition.

A Desert of Resistance

Drug-resistant tuberculosis presents a formidable challenge in the fight against this infectious disease. This study explores a novel combination of drugs, providing a potential oasis of hope for patients facing a desert of resistance.

A Desert of Side Effects

While the drug combination offers promising results, the study acknowledges the presence of potential side effects. The authors highlight the importance of careful monitoring and managing these side effects to ensure patient safety.

Dr.Camel's Conclusion

The desert of drug-resistant tuberculosis is a harsh and unforgiving landscape. This research, like a beacon in the darkness, offers hope for patients struggling with this challenging condition. The study's findings underscore the importance of ongoing research and development of new treatment strategies to combat the threat of drug resistance.

Date :
  1. Date Completed 2020-03-17
  2. Date Revised 2021-01-10
Further Info :

Pubmed ID

32130813

DOI: Digital Object Identifier

PMC6955640

Related Literature

Article Analysis
・Side Effects of pretomanid
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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