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Development, characterization, comparative pharmacokinetic and pharmacodynamic studies of iloperidone solid SMEDDS and liquisolid compact.
Author: NaralaArjun, SuramDinesh, VeerabrahmaKishan
Original Abstract of the Article :
Iloperidone (ILO) is an anti-psychotic, used in schizophrenia. It has low bioavailability (36%) due to low solubility and first pass effect. Oral solid self microemulsifying drug delivery system (SMEDDS) and liquisolid compact (LSC) of ILO were developed. The hypothesis is to test <i>in vivo</i...See full text at original site
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引用元：
https://doi.org/10.1080/03639045.2020.1742142
データ提供：米国国立医学図書館（NLM）
Development, Characterization, Comparative Pharmacokinetic and Pharmacodynamic Studies of Iloperidone Solid SMEDDS and Liquisolid Compact
The quest for better drug delivery systems is an ongoing journey through the desert of pharmaceutical research. This study explores the potential of two novel drug delivery systems, solid self-microemulsifying drug delivery system (SMEDDS) and liquisolid compact (LSC), for improving the bioavailability of iloperidone (ILO), an antipsychotic medication. The researchers developed and characterized these systems, comparing their pharmacokinetic and pharmacodynamic profiles to conventional formulations. Their findings offer valuable insights into the potential of these innovative systems for enhancing the efficacy of ILO, addressing its limitations in terms of low bioavailability and first-pass metabolism.
A New Oasis in the Desert of Drug Delivery
The study found that both the solid SMEDDS and liquisolid compact formulations significantly improved the bioavailability of ILO, demonstrating a notable increase in its absorption compared to conventional formulations. This discovery is like finding a new oasis in the desert of drug delivery, offering a potential solution to improve the effectiveness of this important medication. The researchers also noted that both systems exhibited similar pharmacodynamic effects, suggesting their potential for delivering consistent therapeutic outcomes.
Navigating the Desert of Drug Delivery Innovation
The study highlights the potential of solid SMEDDS and liquisolid compact formulations for enhancing the bioavailability and efficacy of ILO. It encourages further exploration of these innovative drug delivery systems, offering a promising avenue for optimizing the delivery of medications and improving patient outcomes. This study serves as a reminder that the desert of drug delivery research is vast and complex, requiring ongoing innovation and exploration to find new solutions for the challenges of medication administration.
Dr.Camel's Conclusion
This study offers a glimmer of hope in the desert of drug delivery innovation. Solid SMEDDS and liquisolid compact formulations demonstrate the potential to revolutionize drug delivery, enhancing bioavailability and efficacy for medications like ILO. This research highlights the importance of continued exploration and development in the field of drug delivery, striving to find new oases of knowledge and create innovative solutions for patients around the world.
Date :
- Date Completed 2021-02-01
- Date Revised 2021-02-01
Further Info :
Related Literature
English
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