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Assessing the efficacy and safety of fecal microbiota transplantation and probiotic VSL#3 for active ulcerative colitis: A systematic review and meta-analysis.

Author: DangXiaofei, LiuDuanrui, XuMingjie, YangWeihua, ZhouDajie

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Fecal microbiota transplantation (FMT), which involves transferring healthy gut bacteria from a donor to a recipient, is a promising treatment for many gut problems, including C. difficile infection and inflammatory bowel diseases like ulcerative colitis. Changes in the gut bacteria may be a key factor in causing ulcerative colitis, and restoring a healthy balance of bacteria through FMT or taking probiotics might help improve symptoms.
Paper Details　
Original Abstract of the Article :
Fecal microbiota transplantation is an effective treatment for many gastrointestinal diseases, such as Clostridium difficile infection and inflammatory bowel disease, especially ulcerative colitis. Changes in colonic microflora may play an important role in the pathogenesis of ulcerative colitis, an...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077802/

データ提供：米国国立医学図書館（NLM）

Gut Microbiome: A New Frontier for Ulcerative Colitis Treatment

The study delves into the intricate world of the gut microbiome, specifically its role in the development and treatment of ulcerative colitis (UC). The researchers investigate the potential of fecal microbiota transplantation (FMT) and probiotics in managing this inflammatory bowel disease. Using a systematic review and meta-analysis approach, they meticulously analyze the available evidence, highlighting the potential benefits of these therapies in restoring the balance of gut flora and mitigating the symptoms of UC.

A Microbial Symphony: FMT and Probiotics for UC

This research underscores the importance of the gut microbiome in the pathogenesis of ulcerative colitis. FMT, a process of transplanting healthy gut bacteria from a donor to a recipient, and probiotics, which introduce beneficial bacteria into the gut, show promise in managing the disease. The researchers found that these therapies may help restore the balance of gut flora, contributing to symptom relief and potentially slowing the progression of UC.

Unlocking the Secrets of the Gut: A New Path to UC Management

This research sheds light on the potential of harnessing the power of the gut microbiome for UC management. Just as a desert oasis provides respite from the harsh environment, FMT and probiotics offer a potential oasis for those battling UC. However, it's important to note that these therapies are not universally applicable and may have side effects. Consult with a healthcare professional to determine if these approaches are right for you.

Dr. Camel's Conclusion

This study underscores the potential of FMT and probiotics in managing UC. The gut microbiome is like a vast desert, with each organism playing a crucial role. Restoring the balance of this microbial ecosystem through FMT and probiotics may offer a promising avenue for treating this complex disease. More research is needed to fully understand the long-term effects and optimize these therapies.

Date :
  1. Date Completed 2020-06-12
  2. Date Revised 2020-06-12
Further Info :

Pubmed ID

32182248

DOI: Digital Object Identifier

PMC7077802

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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