Slow release oral morphine versus methadone for opioid use disorder in the fentanyl era (pRESTO): Protocol for a non-inferiority randomized clinical trial.

Exploring New Treatment Options for Opioid Use Disorder in the Fentanyl Era

The opioid crisis is a serious public health challenge facing North America. The introduction of illicitly manufactured fentanyl into the drug market has made this crisis even more dangerous. While there are existing pharmacotherapies for opioid use disorder (OUD), such as methadone and buprenorphine, these treatments may not be effective or acceptable for all patients.

This research investigates the potential benefits of slow-release oral morphine (SROM) as an alternative treatment for OUD. Previous studies have shown that SROM may have similar efficacy to methadone in promoting abstinence, and it may even improve patient-reported outcomes. However, the effectiveness and acceptability of SROM in the context of fentanyl use remain unclear.

The study aims to address this knowledge gap by conducting a randomized clinical trial comparing the effectiveness of SROM and methadone in patients with OUD. This trial will provide valuable information about the relative effectiveness and acceptability of these two treatments in the context of fentanyl use.

The Need for Effective and Acceptable Treatments for Opioid Use Disorder

The opioid crisis is a complex and multifaceted problem, and there is no one-size-fits-all solution. This research highlights the need for a range of treatment options that are effective and acceptable to patients. By exploring the potential benefits of SROM, this study aims to expand the available treatment options for OUD.

Understanding the Impact of Fentanyl on Opioid Use Disorder

This study is crucial for understanding the impact of fentanyl on OUD. The presence of fentanyl in the drug supply has made the crisis even more challenging. By comparing the effectiveness of SROM and methadone in the context of fentanyl use, this study could provide valuable insights into how to best address the needs of patients with OUD in this changing landscape.

Dr.Camel's Conclusion

This research is like a beacon of hope in the desert of the opioid crisis. By exploring new treatment options, we can help individuals struggling with OUD find the support and resources they need to overcome their addiction. This study is a testament to the dedication and perseverance of researchers who are working tirelessly to find solutions to this critical public health challenge.