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The Use of Peripheral μ-Opioid Receptor Antagonists (PAMORA) in the Management of Opioid-Induced Constipation: An Update on Their Efficacy and Safety.

Author: ChristoPaul J, LeQuangJo Ann, MagnussonPeter, PergolizziJoseph V

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Peripherally acting μ-opioid receptor antagonists (PAMORAs) are a class of drugs that can reverse opioid-induced constipation (OIC) without affecting the analgesic effects of opioids. PAMORAs antagonize peripheral μ-opioid receptors, which are responsible for OIC, without crossing the blood-brain barrier. Clinical studies have demonstrated the safety and efficacy of PAMORAs in alleviating constipation without diminishing the analgesic effect of opioid therapy.
Paper Details　
Original Abstract of the Article :
Peripherally acting μ-opioid receptor antagonists (PAMORAs) constitute a class of drugs which reverse opioid-induced constipation (OIC) with similar opioid analgesic effects. OIC differs from other forms of constipation in that it is an iatrogenic condition that occurs when an opioid acts on the den...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075239/

データ提供：米国国立医学図書館（NLM）

PAMORAs: Navigating the Desert of Opioid-Induced Constipation

Opioid-induced constipation (OIC) is a common side effect of opioid therapy. It's like a traveler in the desert, struggling to find a way to relieve the discomfort of their journey. This research explores the use of peripherally acting μ-opioid receptor antagonists (PAMORAs) as a solution to this problem. PAMORAs are like a special kind of camel designed to carry a specific cargo, in this case, relief from constipation without affecting the pain-relieving properties of opioids.

PAMORAs: A Promising Oasis in the Desert of Constipation

This research highlights the safety and efficacy of PAMORAs in treating OIC. Clinical studies have shown that these medications can alleviate constipation without diminishing the analgesic effects of opioids. This is like finding a hidden spring in the desert, offering respite from the thirst and dryness. The study reviewed the three main PAMORAs currently available: methyltrexone, naldemedine, and naloxegol.

Finding Relief from OIC: A Collaborative Journey

If you are struggling with OIC, it's essential to work closely with your healthcare provider to find the right treatment options for you. This might involve exploring PAMORAs or other strategies to manage constipation. Remember, there are solutions available to help you navigate this challenging aspect of opioid therapy. This research serves as a reminder that even in the vast desert of health challenges, there are often oases of hope and relief waiting to be discovered.

Dr.Camel's Conclusion

This research sheds light on the promising role of PAMORAs in managing OIC, a common side effect of opioid therapy. As a researcher with a deep understanding of the desert landscape, I am always seeking solutions to the challenges that arise. This research is a testament to the ongoing efforts to find more effective and compassionate ways to manage health conditions, bringing relief and improved quality of life to those in need.

Date :
  1. Date Completed 2021-02-04
  2. Date Revised 2021-02-04
Further Info :

Pubmed ID

32210534

DOI: Digital Object Identifier

PMC7075239

SNS
PICO Info
in preparation
Languages

English

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