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Pre-existing resistance associated polymorphisms to NS3 protease inhibitors in treatment naïve HCV positive Pakistani patients.

Author: AttaullahSobia, KhanHafeez Ullah, KhanSanaullah, MalikMuhammad Arshad, ShahMuhammad Akbar

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Chronic Hepatitis C Virus (HCV) infection is a major health issue, particularly in endemic areas. This study investigated resistance-associated polymorphisms (RAPs) in the HCV NS3 region from DAA-naïve Pakistani patients. The findings suggest a high prevalence of HCV NS3 RAPs, indicating a need for large-scale studies of the NS3 gene before introducing NS3 protease inhibitors in Pakistan.
Paper Details　
Original Abstract of the Article :
Chronic Hepatitis C Virus (HCV) infection is still a major health issue especially in endemic areas where fewer direct-acting virals (DAAs) are treatment options. Some HCV variants are associated with resistance and it reduces DAAs success where pre-existing variants prevail. In this study, we inves...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147739/

データ提供：米国国立医学図書館（NLM）

Pre-Existing Resistance Associated Polymorphisms to NS3 Protease Inhibitors in Treatment Naïve HCV Positive Pakistani Patients

This study delves into the world of Hepatitis C virus (HCV) infection, focusing on the prevalence of resistance-associated polymorphisms (RAPs) in the NS3 region of the HCV genome among treatment-naïve patients in Pakistan. The authors examined a large cohort of HCV-infected patients, meticulously analyzing the NS3 region of the HCV genome to identify pre-existing RAPs that could hinder the effectiveness of direct-acting antiviral (DAA) therapies.

HCV Resistance: A Challenge to Treatment

The study highlights the ongoing challenge of HCV resistance to DAAs, making it crucial to identify pre-existing RAPs in treatment-naïve patients. The authors' comprehensive analysis provides valuable insights into the prevalence of these RAPs in a specific geographic region.

Navigating HCV Treatment

For individuals infected with HCV, understanding the potential challenges associated with treatment is essential. This study underscores the importance of early identification of pre-existing RAPs to guide treatment strategies and optimize the chances of achieving a sustained virological response.

Dr. Camel's Conclusion

This study provides a crucial snapshot of the HCV resistance landscape in Pakistan, offering valuable insights for clinicians treating HCV-infected patients. The research highlights the critical need for comprehensive genetic testing to identify pre-existing RAPs and guide treatment decisions, ultimately improving the effectiveness of HCV therapy.
Date :
  1. Date Completed 2020-07-13
  2. Date Revised 2020-07-13
Further Info :

Pubmed ID

32275694

DOI: Digital Object Identifier

PMC7147739

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English

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