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Altered Energy Metabolism During Early Optic Nerve Crush Injury: Implications of Warburg-Like Aerobic Glycolysis in Facilitating Retinal Ganglion Cell Survival.

Author: LiPing, YeJian, ZhouYuan-Guo, ZhuJingyi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Neurons are metabolically demanding and vulnerable during injury. This study investigated the energy budget alterations that occur early after axon injury and the effects of these changes on neuronal survival. The findings suggest that redirecting metabolic flux toward glycolysis using the drug meclizine may be a potential bioenergetics-based strategy for neuroprotection.
Paper Details　
Original Abstract of the Article :
Neurons, especially axons, are metabolically demanding and energetically vulnerable during injury. However, the exact energy budget alterations that occur early after axon injury and the effects of these changes on neuronal survival remain unknown. Using a classic mouse model of optic nerve-crush in...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340706/

データ提供：米国国立医学図書館（NLM）

Altered Energy Metabolism in Optic Nerve Crush Injury

This study investigates the metabolic changes that occur in the retina and optic nerve following optic nerve crush injury. The researchers found that both the injured nerve and retina increase their energy production through both glycolysis and oxidative phosphorylation. However, the study suggests that an increased reliance on oxidative phosphorylation might be detrimental to retinal ganglion cell (RGC) survival.

Energy Metabolism and Optic Nerve Injury

This research sheds light on the complex metabolic changes that occur following optic nerve injury, highlighting the potential for targeting these metabolic pathways to improve RGC survival.

Understanding Optic Nerve Injury

Optic nerve injury can lead to vision loss. Early intervention and management are crucial for minimizing the impact of injury and preserving visual function.

Dr.Camel's Conclusion

Navigating the complexities of optic nerve injury can be like traversing a desert with shifting sands and unpredictable terrain. This study offers valuable insights into the metabolic responses to injury, suggesting that directing energy production towards glycolysis could be a key strategy for protecting RGCs. It's like finding a hidden oasis in the desert, offering a haven for survival and a chance to restore vision.
Date :
  1. Date Completed 2021-07-19
  2. Date Revised 2021-07-19
Further Info :

Pubmed ID

32277382

DOI: Digital Object Identifier

PMC7340706

Related Literature

Article Analysis
・Effects of meclizine
SNS
PICO Info
in preparation
Languages

English

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