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Comparison of Antioxidant Effects of the Proton Pump-Inhibiting Drugs Omeprazole, Esomeprazole, Lansoprazole, Pantoprazole, and Rabeprazole.

Author: AbedMohammed N, AlassafFawaz A, AlfahadMohanad, JasimMahmood H M, QazzazMohannad E

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Peptic lesions result from an imbalance between aggressive factors and gastro-protective mediators. Antioxidants are crucial for protecting the gastrointestinal lining, and their loss can lead to oxidative stress, a major factor in peptic ulcer development. While proton pump inhibitors effectively reduce acid production, they do not address oxidative damage, which may contribute to future lesions.
Paper Details　
Original Abstract of the Article :
Peptic lesions usually develop when there is an imbalance between aggressive drivers and gastro-protective mediators that guard the lining of the gastrointestinal tract. The most crucial of these mediators are antioxidants, whose loss may predispose to oxidative stress, which is believed to be the m...See full text at original site
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引用元：
https://doi.org/10.1159/000506232

データ提供：米国国立医学図書館（NLM）

Antioxidant Effects of Proton Pump Inhibitors: A Comparative Study

Peptic ulcer disease, a common gastrointestinal disorder, is often associated with oxidative stress, a condition characterized by an imbalance between free radicals and antioxidants. Proton pump inhibitors (PPIs), widely used to treat peptic disorders by reducing gastric acid secretion, have been investigated for their antioxidant properties.

Assessing the Antioxidant Properties of PPIs

This research compares the antioxidant effects of several PPIs, including omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole. The study aims to provide a better understanding of the antioxidant potential of these commonly prescribed medications.

PPIs and Oxidative Stress: A Complex Relationship

The research explores the potential role of PPIs in mitigating oxidative stress, potentially contributing to the management of peptic ulcer disease. The findings could have implications for the selection and use of PPIs in clinical practice.

Dr.Camel's Conclusion

This research sheds light on the antioxidant properties of PPIs, offering valuable insights into their potential role in managing oxidative stress. The findings could contribute to a more informed approach to the selection and use of PPIs in the treatment of peptic disorders.
Date :
  1. Date Completed 2021-03-17
  2. Date Revised 2021-03-17
Further Info :

Pubmed ID

32289807

DOI: Digital Object Identifier

10.1159/000506232

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Article Analysis
・Effects of rabeprazole・Effects of pantoprazole
SNS
PICO Info
in preparation
Languages

English

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