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A Review and Clinical Understanding of Tenofovir: Tenofovir Disoproxil Fumarate versus Tenofovir Alafenamide.

Author: BradleyNicole, LeeYuman, WassnerChanie

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Tenofovir, a nucleotide reverse transcriptase inhibitor, is a key component of many antiretroviral regimens. The newer formulation, tenofovir alafenamide (TAF), has different pharmacokinetics than tenofovir disoproxil fumarate (TDF) and is generally associated with improved tolerability. This manuscript discusses the development, pharmacokinetics, clinical efficacy, adverse effects, monitoring, and clinical applications of both TDF and TAF.
Paper Details　
Original Abstract of the Article :
HIV is a serious chronic medical condition. Significant improvements in antiretroviral therapy have led to a transformation in its management. No curative treatment is available for HIV, and lifelong therapy is required with a combination of agents to control viral replication and prevent complicati...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163232/

データ提供：米国国立医学図書館（NLM）

Tenofovir: A Journey Through the Desert of HIV Treatment

This review examines the history, pharmacokinetics, and clinical applications of tenofovir, a medication used to treat HIV infection. Tenofovir is available in two formulations: tenofovir disoproxil fumarate (TDF) and tenofovir alafenamide (TAF). The authors discuss the unique pharmacokinetic profiles of these two formulations, highlighting their differences in efficacy, safety, and side effects. They also review clinical studies and provide guidance on the use of tenofovir in various clinical settings.

Navigating the Sands of HIV Treatment

This review offers a comprehensive overview of tenofovir, providing valuable information for healthcare providers who manage patients with HIV. The authors highlight the importance of understanding the distinct pharmacokinetic profiles of TDF and TAF to optimize treatment strategies and minimize potential side effects.

Finding a Path to Better HIV Management

The research underscores the ongoing efforts to improve HIV treatment options. Tenofovir, with its distinct formulations and evolving clinical applications, represents a significant advancement in the field. The authors emphasize the importance of continued research to develop even safer and more effective treatments for HIV.

Dr.Camel's Conclusion

This review explores the journey of tenofovir through the desert of HIV treatment, highlighting the progress made in finding new and effective medications to combat this challenging disease.

Date :
  1. Date Completed 2021-05-19
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

32295453

DOI: Digital Object Identifier

PMC7163232

SNS
PICO Info
in preparation
Languages

English

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