Lipopolysaccharides transport during fat absorption in rodent small intestine.

Author: AkibaYasutada, KatoIkuo, KaunitzJonathan D, KuwaharaAtsukazu, MarutaKoji, NarimatsuKazuyuki, SaidHyder, TakajoTakeshi

Paper Details 
Original Abstract of the Article :
Lipopolysaccharides (LPS) are potent pro-inflammatory molecules that enter the systemic circulation from the intestinal lumen by uncertain mechanisms. We investigated these mechanisms and the effect of exogenous glucagon-like peptide-2 (GLP-2) on LPS transport in the rodent small intestine. Transmuc...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311662/

データ提供:米国国立医学図書館(NLM)

Lipopolysaccharides and Fat Absorption: A Journey Through the Gut

Lipopolysaccharides (LPS) are molecules found in bacteria that can trigger inflammation in our bodies. This study examines how LPS travels through the gut during fat absorption. The authors discovered that LPS can cross the intestinal barrier during fat digestion, piggybacking on fatty acids. This process is influenced by a protein called CD36 and a hormone called GLP-2. The study also found that GLP-2 can block LPS from entering the bloodstream, potentially preventing inflammation.

Unraveling the Mysteries of the Gut

This research uncovers a fascinating and previously unknown mechanism of LPS transport during fat absorption. It sheds light on the intricate connections between the gut microbiome, fat digestion, and the immune system. These findings could have important implications for understanding and managing inflammatory conditions.

Health Implications and Lifestyle Applications

This study highlights the importance of a healthy gut microbiome and a balanced diet. It also suggests that GLP-2, a hormone naturally produced in the gut, could play a role in regulating inflammation. Further research on the role of GLP-2 in regulating LPS transport may lead to new treatments for inflammatory conditions.

Dr.Camel's Conclusion

This study is like a journey through the fascinating and complex landscape of the human gut. It reveals hidden pathways and mechanisms that contribute to our health and well-being. Just as a camel navigates the intricate network of desert trails, researchers are uncovering the secrets of the gut microbiome, revealing its profound impact on our overall health.

Date :
  1. Date Completed 2020-10-15
  2. Date Revised 2021-06-02
Further Info :

Pubmed ID

32390462

DOI: Digital Object Identifier

PMC7311662

Related Literature

SNS
PICO Info
in preparation
Languages

English

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