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Optimized clinical management of Parkinson's disease with opicapone. Recommendations from Spanish experts.

Author: García Ruiz-EspigaP, Linazasoro-CristóbalG, Luquin-PiudoM R, López Del ValL J, López-ManzanaresL, Martínez-CastrilloJ C, MirP, Pagonabarraga-MoraJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Opicapone is an effective COMT inhibitor for controlling motor fluctuations in Parkinson's disease, regardless of levodopa dose or the use of other antiparkinsonian drugs. The ideal patient for initiating treatment with opicapone is one with mild motor fluctuations.
Paper Details　
Original Abstract of the Article :
Motor fluctuations are frequently seen in Parkinson disease patients on chronic treatment with levodopa. Management of motor fluctuation includes the addition of catechol-O-methyl transferase (COMT) inhibitors. Opicapone is a recent and selective third-generation COMT inhibitor which achieves marked...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/32515486

データ提供：米国国立医学図書館（NLM）

Optimizing Parkinson's Disease Management with Opicapone

Parkinson's disease, a chronic neurodegenerative disorder, presents significant challenges for patients and healthcare professionals alike. This study explores the role of opicapone, a novel COMT inhibitor, in managing motor fluctuations, a common symptom of Parkinson's disease. The authors present a consensus from Spanish neurologists on the optimal use of opicapone, drawing on both clinical trial data and their extensive experience in treating motor fluctuations.

Opicapone: A Potential Solution for Motor Fluctuations

The consensus among the experts is that opicapone is an effective drug in controlling motor fluctuations, regardless of the dose of levodopa or other antiparkinsonian drugs used. This is significant because it offers a potential solution for a common and debilitating symptom of Parkinson's disease. The experts recommend opicapone for patients with mild motor fluctuations, as the balance between clinical efficacy and adverse effects is more favorable in these individuals.

Improving Quality of Life for Parkinson's Patients

The ability to effectively manage motor fluctuations can significantly improve the quality of life for individuals with Parkinson's disease. This study provides valuable guidance for healthcare professionals, outlining the potential benefits of opicapone and offering insights into the optimal use of this medication. By understanding the nuances of this medication, healthcare professionals can make informed decisions about treatment, ultimately leading to better outcomes for their patients.

Dr.Camel's Conclusion

Navigating the complexities of Parkinson's disease can be akin to traversing a shifting desert landscape, constantly adapting to the challenges of motor fluctuations. This study offers a valuable guidepost in this journey, highlighting the potential benefits of opicapone in managing these fluctuations and ultimately improving the quality of life for individuals with Parkinson's disease.

Date :
  1. Date Completed 2021-05-10
  2. Date Revised 2021-05-10
Further Info :

Pubmed ID

32515486

DOI: Digital Object Identifier

rn2019340

SNS
PICO Info
in preparation
Languages

English

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