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Naldemedine: A New Option for OIBD.

Author: ColuzziFlaminia, PergolizziJoseph, ScerpaMaria Sole

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Naldemedine, a peripherally acting mu-opioid receptor antagonist (PAMORA), has emerged as a well-tolerated treatment option for opioid-induced bowel dysfunction (OIBD), alleviating constipation without affecting analgesia or causing opioid withdrawal symptoms.
Paper Details　
Original Abstract of the Article :
Opioid-induced bowel dysfunction (OIBD) is a common complication in long-term opioid users and abusers. It is a burdensome condition, which significantly limits quality of life and is associated with increasing health costs. OIBD affects up to 60% of patients with chronic non-cancer pain and over 80...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266404/

データ提供：米国国立医学図書館（NLM）

Naldemedine: A New Hope for Opioid-Induced Bowel Dysfunction (OIBD)

Navigating the challenging terrain of chronic pain management, researchers continue to seek solutions for opioid-induced bowel dysfunction (OIBD), a common and debilitating side effect. This study investigates naldemedine, a novel drug designed to alleviate constipation without compromising the analgesic effects of opioids. This is a crucial advancement as OIBD affects a significant portion of patients relying on opioids for pain relief. The study delves into the drug's mechanism of action and explores its clinical efficacy and safety profile.

Naldemedine: A Promising Treatment Option for OIBD

The study concludes that naldemedine offers a viable treatment option for OIBD. This drug successfully reduces constipation without hindering the pain-relieving effects of opioids. Moreover, naldemedine is well-tolerated by patients, further bolstering its appeal.

A Step Forward in Pain Management: Balancing Relief and Well-being

The development of naldemedine is a significant step forward in managing chronic pain. By effectively addressing the issue of OIBD without jeopardizing pain relief, naldemedine enhances the quality of life for patients struggling with chronic pain. This research represents a beacon of hope, guiding us towards a more balanced approach to pain management, where relief is coupled with overall well-being.

Dr. Camel's Conclusion

As a researcher, I'm delighted to see advancements in pain management that prioritize both relief and well-being. Naldemedine's targeted approach to OIBD holds immense potential to improve the lives of countless individuals. This research showcases the unwavering dedication of scientists to discover innovative solutions for complex health challenges, reminding us that even in the vast desert of medical mysteries, hope and progress can emerge.
Date :
  1. Date Completed n.d.
  2. Date Revised 2020-09-28
Further Info :

Pubmed ID

32547183

DOI: Digital Object Identifier

PMC7266404

Related Literature

Article Analysis
・Side Effects of naldemedine
SNS
PICO Info
in preparation
Languages

English

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