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Sodium bicarbonate to improve physical function in patients over 60 years with advanced chronic kidney disease: the BiCARB RCT.

Author: AvenellAlison, BandMargaret, ChongHuey, DonnanPeter T, HampsonGeeta, HuMay Khei, KalraPhilip A, KennedyGwen, LambEdmund, LittlefordRoberta, McNameePaul, PlewsDeirdre, RauchhausPetra, SoizaRoy L, SumukadasDeepa, WarwickGraham, WithamMiles D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Oral sodium bicarbonate did not improve a range of health measures in older adults with chronic kidney disease (CKD) category 4 or 5 and mild acidosis. There was no significant treatment effect on physical function, quality of life, markers of renal function, bone turnover, or vascular health. Oral bicarbonate is unlikely to be cost-effective for use in this patient group.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Advanced chronic kidney disease is common in older people and is frequently accompanied by metabolic acidosis. Oral sodium bicarbonate is used to treat this acidosis, but evidence is lacking on whether or not this provides a net gain in health or quality of life for older people. OBJECT...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336221/

データ提供：米国国立医学図書館（NLM）

Bicarbonate Therapy for Older Adults with Kidney Disease: A Search for Benefits

Metabolic acidosis, a common condition in older adults with advanced chronic kidney disease, can negatively impact health and well-being. This study investigates the potential benefits of oral sodium bicarbonate therapy in older adults with chronic kidney disease and mild acidosis. The study aims to determine whether bicarbonate therapy improves physical function, quality of life, and other health markers in this population.

A Quest for Improvement: Bicarbonate's Effect on Kidney Disease

The study, a randomized controlled trial, compared the effects of oral bicarbonate therapy to placebo in older adults with chronic kidney disease. While bicarbonate therapy did not lead to significant improvements in physical function or other health outcomes, the study highlights the need for further research to determine the optimal dose and potential benefits of bicarbonate therapy in different patient subgroups.

Tailoring Treatment: A Personalized Approach

The study's findings suggest that a one-size-fits-all approach to bicarbonate therapy may not be effective for all older adults with chronic kidney disease. Further research is needed to determine which subgroups might benefit from bicarbonate therapy and how to optimize its use for improved outcomes.

Dr.Camel's Conclusion

This study explores the potential benefits of oral sodium bicarbonate therapy for older adults with chronic kidney disease and mild acidosis. While the study did not find significant benefits, it emphasizes the need for continued research to refine treatment strategies and identify potential subgroups who might benefit from this approach.

Date :
  1. Date Completed 2021-09-13
  2. Date Revised 2021-09-13
Further Info :

Pubmed ID

32568065

DOI: Digital Object Identifier

PMC7336221

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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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