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Protective Effects of N-Acetylcysteine against Radiation-Induced Oral Mucositis In Vitro and In Vivo.

Author: JangJeon Yeob, KangHami, KangSung Un, KimChul-Ho, KimHaeng Jun, LeeYun Sang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Radiation-induced oral mucositis is a common side effect of radiation therapy. The authors suggest that inhibiting reactive oxygen species (ROS) generation may suppress autophagy, potentially alleviating radiation-induced oral mucositis.
Paper Details　
Original Abstract of the Article :
Radiation-induced oral mucositis limits delivery of high-dose radiation to targeted cancers. Therefore, it is necessary to develop a treatment strategy to alleviate radiation-induced oral mucositis during radiation therapy. We previously reported that inhibiting reactive oxygen species (ROS) generat...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7577823/

データ提供：米国国立医学図書館（NLM）

Protecting Against Radiation-Induced Oral Mucositis: A New Weapon in the Fight

The side effects of **radiation therapy** can be as challenging to manage as navigating a scorching desert. This study investigates the potential of **N-acetylcysteine** to protect against **radiation-induced oral mucositis**, a painful inflammation of the mouth lining, a common and debilitating side effect of radiation therapy. The researchers explored the mechanisms by which N-acetylcysteine might alleviate this side effect.

A Promising Protective Effect

This research, like a desert oasis offering a respite from the scorching sun, reveals the potential of N-acetylcysteine to protect against radiation-induced oral mucositis. The study found that N-acetylcysteine, an antioxidant, can effectively reduce the severity of oral mucositis in both in vitro and in vivo models. The researchers believe that the antioxidant properties of N-acetylcysteine may play a key role in protecting cells from the damaging effects of radiation.

Improving the Quality of Life for Cancer Patients

This research, like a desert guide providing essential resources to weary travelers, offers hope for improving the quality of life for cancer patients undergoing radiation therapy. The study's findings suggest that N-acetylcysteine may have a significant role to play in managing the side effects of radiation therapy. This research underscores the importance of exploring novel strategies to alleviate the discomfort and complications associated with cancer treatment.

Dr.Camel's Conclusion

This study, like a camel caravan seeking a safe passage through a dangerous desert, reveals the potential of N-acetylcysteine to protect against radiation-induced oral mucositis. The research suggests that this antioxidant may offer a valuable therapeutic strategy for mitigating the side effects of radiation therapy, ultimately improving the quality of life for cancer patients undergoing this crucial treatment.

Date :
  1. Date Completed 2021-06-21
  2. Date Revised 2022-04-17
Further Info :

Pubmed ID

32599978

DOI: Digital Object Identifier

PMC7577823

Related Literature

Article Analysis
・Effects of acetylcysteine oral inhalation
SNS
PICO Info
in preparation
Languages

English

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