Paper Details

  1. Home
  2. Paper Details

Adverse perinatal outcomes associated with antiretroviral therapy regimens: systematic review and network meta-analysis.

Author: HemelaarJoris, HoneymanSusan, KennedyStephen H, KirtleyShona, NesbittCharlotte, Tshivuila-MatalaChrystelle O O

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review and network meta-analysis assessed adverse perinatal outcomes associated with different antenatal antiretroviral therapy (ART) regimens. Analysis of 10 randomized controlled trials involving 6285 women found that LPV/r-containing regimens were associated with the highest risks of adverse perinatal outcomes, including low birthweight, very low birthweight, preterm birth, spontaneous preterm birth, very preterm birth, small-for-gestational-age, and neonatal death. The study highlights the need to carefully consider the potential risks and benefits of different ART regimens in pregnancy.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Assess adverse perinatal outcomes associated with antenatal antiretroviral therapy (ART) regimens. DESIGN: Systematic review and network meta-analysis of randomized controlled trials (RCTS). METHODS: We conducted a systematic literature review by searching PubMed, CINAHL, Global Health,...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/32701581

データ提供：米国国立医学図書館（NLM）

Adverse Perinatal Outcomes Associated with Antiretroviral Therapy

This research delves into the complex and challenging world of HIV/AIDS, a disease that has had a devastating impact on global health. The authors conducted a comprehensive systematic review and network meta-analysis of randomized controlled trials to assess the potential risks associated with different antiretroviral therapy (ART) regimens during pregnancy. The study found that some ART regimens, particularly those containing lopinavir/ritonavir (LPV/r), were associated with a higher risk of adverse perinatal outcomes, such as preterm birth, low birthweight, and small-for-gestational-age. This is like discovering that certain paths through the desert may lead to dangerous cliffs or areas of scarce water, emphasizing the need for careful navigation in the world of HIV/AIDS treatment.

Navigating the Desert of HIV/AIDS Treatment

The study underscores the importance of careful consideration when choosing ART regimens for pregnant women with HIV. The findings suggest that while ART is essential for preventing mother-to-child transmission, some regimens may carry higher risks of adverse perinatal outcomes. This is like choosing a safe and reliable path through the desert, avoiding treacherous areas that could pose risks to the journey.

Finding the Right Oasis: Personalized HIV/AIDS Treatment

The research highlights the need for individualized treatment plans for pregnant women with HIV. The best ART regimen for a particular patient will depend on their individual circumstances, including their health status, viral load, and treatment history. It's like finding the perfect oasis in the desert, a journey that requires careful consideration and a deep understanding of the terrain.

Dr.Camel's Conclusion

This research is a reminder that the desert of HIV/AIDS treatment is vast and complex, and that finding the right path requires careful navigation and an awareness of the changing landscape. The study provides valuable insights into the potential risks associated with different ART regimens, offering clinicians the information they need to make informed decisions for their patients.

Date :
  1. Date Completed 2021-02-19
  2. Date Revised 2021-02-19
Further Info :

Pubmed ID

32701581

DOI: Digital Object Identifier

00002030-202009010-00008

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.