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Effects of Calcium and Annatto Tocotrienol Supplementation on Bone Loss Induced by Pantoprazole in Male Rats.
Author: ChinKok-Yong, KamalullohRhivaldy Faahim, MohamadNur Vaizura, Mohd ArlamsyahAzlan, SoelaimanIma Nirwana, ThongBenjamin Ka Seng, TrilianaRahma, WongSok Kuan
Original Abstract of the Article :
Label="PURPOSE" NlmCategory="OBJECTIVE">Prolonged use of proton pump inhibitors may cause bone loss, and limited therapeutic agents are available to prevent this skeletal side effect. The combination of annatto tocotrienol, a bone anabolic agent, with calcium presents a novel strategy to prevent bon...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7342557/
データ提供:米国国立医学図書館(NLM)
Calcium and Annatto Tocotrienol: A Novel Approach to Preventing Bone Loss
The desert of bone health can be a fragile landscape, especially when it comes to the potential side effects of medications. This study investigates the effects of calcium and annatto tocotrienol supplementation on bone loss induced by pantoprazole, a common proton pump inhibitor. The authors conducted a study on male rats to compare the effects of calcium alone, calcium combined with annatto tocotrienol, and calcium combined with vitamin D3 (Caltrate Plus). Their goal was to explore novel strategies for preventing bone loss associated with pantoprazole therapy.
Promising Results
The study found that both annatto tocotrienol and vitamin D3, when combined with calcium, were effective in preventing bone loss caused by pantoprazole. This suggests that these combinations may offer a promising strategy for mitigating the skeletal side effects of proton pump inhibitors. The authors highlight the potential of annatto tocotrienol as a novel bone anabolic agent.
Protecting Bone Health
This study emphasizes the importance of considering the potential impact of medications on bone health. It suggests that combining calcium with other bone-building nutrients, such as annatto tocotrienol or vitamin D3, may help to prevent bone loss associated with proton pump inhibitors. The findings encourage further research into the use of annatto tocotrienol as a therapeutic agent for bone health.
Dr. Camel's Conclusion
This study, like a well-hidden oasis in the desert, reveals a promising new approach to protecting bone health. The authors' meticulous research showcases the potential of annatto tocotrienol as a novel bone anabolic agent, offering hope for mitigating the skeletal side effects of proton pump inhibitors and preventing bone loss. Their findings encourage further research into this promising therapeutic strategy.
Date :
- Date Completed 2021-06-04
- Date Revised 2022-04-16
Further Info :
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