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State-of-the-Art Management of Hyperphosphatemia in Patients With CKD: An NKF-KDOQI Controversies Perspective.

Author: GutiérrezOrlando M, JimenezElizabeth Yakes, KendrickJessica, KovesdyCsaba P, KramerHolly J, SciallaJulia J, UribarriJaime

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Phosphate binders are commonly used to lower high phosphate levels in patients with chronic kidney disease (CKD) or kidney failure. While guidelines recommend lowering phosphate levels, there's uncertainty about the best type of binder to use. Many different binders are available, but no clinical trials have shown that one type is better than another. Using binders adds to the number of pills patients need to take and can be expensive. More research is needed to determine the optimal use and type of phosphate binder for these patients.
Paper Details　
Original Abstract of the Article :
Phosphate binders are among the most common medications prescribed to patients with kidney failure receiving dialysis and are often used in advanced chronic kidney disease (CKD). In patients with CKD glomerular filtration rate category 3a (G3a) or worse, including those with kidney failure who are r...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/32771650

データ提供：米国国立医学図書館（NLM）

Navigating the Complex World of Phosphate Binders in CKD

This research focuses on hyperphosphatemia, a condition characterized by high levels of phosphate in the blood, often found in patients with chronic kidney disease (CKD). The study delves into the use of phosphate binders, medications prescribed to control phosphate levels, particularly in patients undergoing dialysis. The authors address the controversy surrounding the use of these binders, acknowledging the lack of definitive evidence on the superiority of one class over another. They also highlight the substantial pill burden and out-of-pocket costs associated with phosphate binder therapy, as well as potential side effects.

Finding the Right Balance: Phosphate Binders in CKD

The authors present a comprehensive overview of the evidence base surrounding phosphate binder use in CKD and kidney failure. They compare different classes of binders and discuss the challenges of choosing the most appropriate treatment for individual patients. They emphasize the need for careful consideration of factors such as patient characteristics, cost, and potential side effects when making treatment decisions.

Making Informed Choices: Considerations for Patients with CKD

In essence, this study underscores the complexity of managing hyperphosphatemia in CKD. It encourages a nuanced approach, taking into account the individual patient's needs and the potential risks and benefits of different treatment options. It also emphasizes the importance of ongoing research to improve our understanding of the most effective and safe ways to control phosphate levels in CKD.

Dr.Camel's Conclusion

This research is like a long, winding caravan journey across the desert. Navigating the complex world of phosphate binders for CKD patients is a journey with many twists and turns. We need to consider all the factors – the patient's individual needs, the cost of treatment, and the potential side effects – just as a caravan leader must consider all the obstacles and resources in the desert. The goal is to reach the destination – a healthy and well-managed CKD patient – with minimal risks and complications.
Date :
  1. Date Completed 2021-02-04
  2. Date Revised 2023-11-11
Further Info :

Pubmed ID

32771650

DOI: Digital Object Identifier

NIHMS1647215

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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