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Non-Dopaminergic Treatments for Motor Control in Parkinson's Disease: An Update.
Author: BhowmickSuvorit Subhas, FoxSusan H, Gonzalez-LatapiPaulina, SaranzaGerard
Original Abstract of the Article :
Glutamatergic, noradrenergic, serotonergic, and cholinergic systems play a critical role in the basal ganglia circuitry. Targeting these non-dopaminergic receptors remains a focus of ongoing research to improve Parkinson's disease (PD) motor symptoms, without the potential side effects of dopamine r...See full text at original site
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引用元:
https://doi.org/10.1007/s40263-020-00754-0
データ提供:米国国立医学図書館(NLM)
Beyond Dopamine: Exploring Non-Dopaminergic Treatments for Parkinson's Disease
The management of [Parkinson's disease (PD)], a neurodegenerative disorder characterized by motor dysfunction, often relies on [dopamine replacement therapy]. However, the long-term use of [dopamine] can lead to side effects. This review explores the potential of targeting [non-dopaminergic receptors] in the brain to improve [motor control] in PD patients. The researchers highlight the roles of [glutamatergic, noradrenergic, serotonergic, and cholinergic systems] in the brain and their potential as targets for therapeutic intervention. While no single non-dopaminergic drug has yet demonstrated significant long-term efficacy as monotherapy, several drugs are being investigated for specific motor complications of PD, such as [motor fluctuations and dyskinesia]. This review underscores the ongoing search for novel non-dopaminergic therapies to improve motor control in PD patients and address the limitations of [dopamine replacement therapy].
A New Oasis in the Desert of Parkinson's: Exploring Non-Dopaminergic Pathways
The study's findings offer hope for patients with PD by highlighting the potential of targeting [non-dopaminergic receptors] to improve motor control. Imagine a desert with a network of hidden oases, each offering a unique source of water and sustenance. Similarly, the brain offers a multitude of potential pathways to address PD symptoms. This research encourages further investigation into [non-dopaminergic targets] to develop new therapies that may alleviate the burden of PD and offer patients a more fulfilling life.
The Quest for a Cure: Expanding the Horizons of Parkinson's Treatment
The exploration of [non-dopaminergic treatments] for PD highlights the ongoing search for more effective and well-tolerated therapies. Imagine a desert traveler exploring new routes and seeking alternative sources of water. Similarly, researchers are exploring new avenues in PD treatment, searching for alternative pathways to alleviate symptoms and improve patients' quality of life. This research underscores the continuous efforts to understand the complexities of PD and develop new therapies to address this debilitating condition.
Dr.Camel's Conclusion
This review underscores the importance of exploring [non-dopaminergic targets] in the treatment of PD, offering a potential avenue for addressing the limitations of [dopamine replacement therapy]. While further research is needed to validate these findings, the pursuit of non-dopaminergic therapies holds promise for improving the lives of patients with PD.
Date :
- Date Completed 2021-10-20
- Date Revised 2021-10-20
Further Info :
Related Literature
English
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