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Biochemical and histopathologic assessment of effects of acitretin on epiphyseal growth plate in rats.
Author: BilgiliSerap Gunes, BulutGulay, CalkaOmer, CelikHuseyin Tugrul, KaradagAyse Serap, OguztuzunSerpil, OnderHacı, OnderSevda
Original Abstract of the Article :
INTRODUCTION: Acitretin is a commonly used retinoid in dermatology. Although there are generally known side effects, the effects on the epiphyseal plaque and bone metabolism are not clear in the literature. AIM: To histopathologically investigate the effects on the epiphyseal plate and assess varia...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7394155/
データ提供:米国国立医学図書館(NLM)
Acitretin and Epiphyseal Growth Plate: A Closer Look at Potential Side Effects
This research delves into the realm of [pharmacology] and investigates the potential effects of acitretin, a commonly used retinoid in dermatology, on the epiphyseal growth plate in rats. The researchers conducted a study to histopathologically assess the effects of acitretin on the growth plate and to evaluate changes in bone metabolism. The study found that acitretin caused degeneration of the epiphyseal growth plate, highlighting the potential for bone growth-related side effects. This research provides crucial insights into the potential risks associated with acitretin treatment, emphasizing the importance of careful monitoring and consideration of alternative treatment options.
A Deeper Understanding of Acitretin's Effects
The study found that while acitretin did not cause clear thinning of the epiphyseal plate, it did lead to degeneration, suggesting a potential impact on bone growth. This finding is important for understanding the potential risks associated with acitretin treatment, particularly in patients with developing bone structures. The research suggests that careful monitoring of bone growth and potential side effects is crucial during acitretin therapy.
Navigating the Risks and Benefits of Acitretin
This research underscores the importance of weighing the risks and benefits of acitretin treatment. While acitretin can be an effective treatment option for certain dermatological conditions, it is crucial to be aware of its potential impact on bone growth. Healthcare providers should carefully consider the individual patient's needs and potential risks before prescribing acitretin, ensuring that the benefits outweigh the potential side effects.
Dr.Camel's Conclusion
This research, like a camel navigating a treacherous desert path, reveals the potential for unexpected consequences of acitretin treatment. While acitretin can be a valuable tool for managing skin conditions, it's essential to be aware of its potential impact on bone growth. This research serves as a reminder that navigating the world of pharmaceuticals requires careful consideration of potential risks and benefits, ensuring the best possible outcomes for patients.
Date :
- Date Completed n.d.
- Date Revised 2022-04-16
Further Info :
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