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Tolerability of tretinoin lotion 0.05% for moderate to severe acne vulgaris: a post hoc analysis in a black population.

Author: BhatiaNeal D, Cook-BoldenFran E, GueninEric, WerschlerWilliam P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Acne is a common skin condition among Black patients, who often experience more complications compared to those with lighter skin. Dark spots (post-inflammatory hyperpigmentation) are a significant concern for Black patients with acne, often prompting them to seek treatment. Retinoids can treat both acne and dark spots, but they can also cause irritation, which could worsen dark spots. A new lotion formulation of tretinoin has been developed as a gentler alternative for Black patients who might be sensitive to other forms of tretinoin or concerned about dark spots.
Paper Details　
Original Abstract of the Article :
Acne vulgaris (acne) is the most common dermatologic disorder seen in black patients. However, data are lacking on the effects of treatments, such as topical retinoids. Acne in black patients is frequently associated with postinflammatory hyperpigmentation (PIH), which can be of greater concern than...See full text at original site
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引用元：
https://doi.org/10.12788/cutis.0059

データ提供：米国国立医学図書館（NLM）

Tretinoin Lotion for Acne Vulgaris in Black Patients

Acne vulgaris, a common skin condition, can be a challenging desert to navigate, particularly for Black patients. This research, like a careful camel traversing a scorching landscape, explores the tolerability and efficacy of tretinoin lotion 0.05% in treating acne in this population. The study highlights the unique concerns of postinflammatory hyperpigmentation (PIH), which often motivates Black patients to seek dermatological care.

Tretinoin Lotion: A Cool Breeze in the Desert of Acne

Tretinoin, a potent retinoid, has shown potential for treating both acne and PIH. The study aimed to assess the tolerability of a lotion formulation of tretinoin, which provides a gentler alternative for Black patients who may experience sensitivity to other formulations. While the study did not provide specific data on efficacy, it underscores the need for alternative treatment options for acne in Black patients, particularly those with PIH concerns.

Navigating the Desert of Acne Treatment

The potential for retinoids to induce irritant contact dermatitis, which could exacerbate PIH, remains a concern. This research highlights the need for careful consideration of treatment options and formulations tailored to the specific needs of Black patients, considering the unique challenges they face in managing acne and PIH. A thoughtful approach to treatment, like carefully navigating a challenging desert landscape, is crucial for achieving positive outcomes.

Dr.Camel's Conclusion

This research emphasizes the need for tailored treatment approaches to acne in Black patients. The study underscores the importance of considering the unique challenges associated with PIH and finding alternative treatment options that minimize the risk of irritation. Further research is needed to fully understand the efficacy and long-term effects of tretinoin lotion in this population.

Date :
  1. Date Completed 2021-07-13
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

32915939

DOI: Digital Object Identifier

10.12788/cutis.0059

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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