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Neuromodulation for Apathy in Alzheimer's Disease: A Double-Blind, Randomized, Sham-Controlled Pilot Study.

Author: BoozerEugenia M, CacedaRicardo, DennisRichard A, HunterCassandra R, LensingShelly Y, PadalaKalpana P, PadalaPrasad R, ParkesChristopher M

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Apathy, a lack of motivation and interest, is common in people with Alzheimer's disease (AD) and can lead to faster worsening of the disease, long-term disability, and even shorter lifespans. Unfortunately, there are limited medication options to treat apathy in these individuals.
Paper Details　
Original Abstract of the Article :
Apathy, a profound loss of motivation, initiation, and goal directed cognition, is a common comorbidity of Alzheimer's disease (AD). The presence of apathy is associated with rapid progression of AD, long-term impairment, disability, and higher mortality. Pharmacological treatments of apathy are lim...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683089/

データ提供：米国国立医学図書館（NLM）

Neuromodulation for Apathy in Alzheimer's Disease: A Journey Through the Desert of Cognitive Decline

Alzheimer's disease, a relentless journey through the desert of cognitive decline, is often accompanied by apathy, a profound loss of motivation and interest. This pilot study investigates the potential of neuromodulation, a technique that uses electrical stimulation to modulate brain activity, as a treatment for apathy in Alzheimer's disease. Researchers conducted a double-blind, randomized, sham-controlled trial, carefully comparing the effects of neuromodulation with a placebo. While this study was relatively small, it offered a promising glimpse into the potential of neuromodulation for addressing apathy in Alzheimer's disease, suggesting that it could offer a novel and targeted approach to managing this challenging symptom.

A Glimpse of Hope: Neuromodulation for Apathy in Alzheimer's Disease

This pilot study, like a small spring of water in the desert, offers a glimmer of hope for those struggling with apathy in Alzheimer's disease. The researchers' findings suggest that neuromodulation could be a valuable tool for improving motivation and engagement in individuals with Alzheimer's disease, offering a potential avenue for improving their quality of life.

Health Benefits and Daily Application

While neuromodulation is still in its early stages of development, this study provides valuable insights into its potential for managing apathy in Alzheimer's disease. Further research is needed to fully understand its effectiveness and long-term implications, but it offers a promising new direction in the search for treatments that address the multifaceted challenges of Alzheimer's disease.

Dr. Camel's Conclusion

This pilot study explores the potential of neuromodulation for addressing apathy in Alzheimer's disease, a condition that can significantly impact quality of life. While further research is needed, the initial findings offer a promising glimpse into the potential of this innovative approach. Just as a camel finds strength and resilience in the face of adversity, individuals with Alzheimer's disease, with the support of innovative treatments and dedicated caregivers, can continue to navigate the challenges of this complex condition and find meaningful ways to live their lives to the fullest.

Date :
  1. Date Completed 2021-09-10
  2. Date Revised 2021-09-10
Further Info :

Pubmed ID

32925060

DOI: Digital Object Identifier

PMC7683089

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Article Analysis
・Effective treatment of alzheimer's disease
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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