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Effects of eslicarbazepine as add-on therapy on sleep architecture in temporal lobe epilepsy: results from "Esleep" study.

Author: CaccamoMarco, CasciatoSara, CentonzeDiego, D'AnielloAlfredo, Di GennaroGiancarlo, Di GioiaBattista, RomigiAndrea, TestaFederica, VitraniGiuseppe

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Eslicarbazepine (ESL) as add-on therapy in temporal lobe epilepsy (TLE) showed significant improvement in sleep continuity as measured by cyclic alternating pattern (CAP) parameters. This suggests that ESL may positively modulate sleep fragmentation and enhance sleep quality.
Paper Details　
Original Abstract of the Article :
RATIONALE: Studies looking at the effect of antiseizure medications (ASMs) on the sleep microstructure of subjects with epilepsy are scarce. This study aims to evaluate the impact of eslicarbazepine (ESL) as add-on therapy on the sleep microstructure in temporal lobe epilepsy (TLE). METHODS: Twelve...See full text at original site
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引用元：
https://doi.org/10.1016/j.sleep.2020.06.033

データ提供：米国国立医学図書館（NLM）

Eslicarbazepine: A Potential Oasis in the Sleepless Desert of Temporal Lobe Epilepsy

Temporal lobe epilepsy (TLE) can disrupt sleep and significantly impact quality of life. This study investigates the effects of eslicarbazepine (ESL), an antiseizure medication, on sleep architecture in patients with TLE. The authors evaluate the impact of ESL as add-on therapy on various sleep parameters, including sleep efficiency, REM sleep percentage, and cyclic alternating pattern (CAP), using polysomnography and subjective sleep assessments.

Eslicarbazepine: A Potential Oasis in the Sleepless Desert of Temporal Lobe Epilepsy

The study's findings suggest that ESL may positively modulate sleep fragmentation in patients with TLE, improving sleep quality. The authors demonstrate that ESL significantly reduced CAP parameters, indicating an improvement in sleep continuity and reduced fragmentation. This finding is encouraging, as it suggests that ESL may help individuals with TLE find a more peaceful and restful sleep, potentially leading to improved overall well-being.

Eslicarbazepine: A Potential Oasis in the Sleepless Desert of Temporal Lobe Epilepsy

This research highlights the importance of considering the impact of antiseizure medications on sleep patterns in patients with TLE. The study's findings suggest that ESL may offer a valuable therapeutic option for managing both seizure activity and sleep disturbance in patients with TLE. This research encourages further investigation into the effects of ESL on sleep and its potential to improve the quality of life for individuals with TLE.

Dr. Camel's Conclusion

The desert of epilepsy can be a sleepless and challenging landscape, but this study suggests that eslicarbazepine may offer a welcome oasis for those suffering from temporal lobe epilepsy. While more research is needed, the findings of this study provide hope that ESL may help individuals with TLE find a more restful sleep, improving their overall well-being.

Date :
  1. Date Completed 2021-06-21
  2. Date Revised 2021-06-21
Further Info :

Pubmed ID

32927378

DOI: Digital Object Identifier

10.1016/j.sleep.2020.06.033

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・Effects of eslicarbazepine
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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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