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Flupenthixol in chronic schizophrenic inpatients: a controlled comparison with haloperidol.

Author: BeningerR J, DelvaN J, EhmannT S

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Overview

Haloperidol was more effective in reducing psychopathology than flupenthixol, but both drugs had similar levels of side effects. The study did not find evidence that flupenthixol is effective in activating chronic patients or alleviating affective symptoms.
Paper Details　
Original Abstract of the Article :
Two neuroleptics having different effects at dopamine receptors were administered to chronic schizophrenic inpatients to compare their therapeutic efficacy and ability to produce side effects. Haloperidol appeared to produce lower levels of psychopathology than flupenthixol but similar levels of sid...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/3298328

データ提供：米国国立医学図書館（NLM）

Chronic Schizophrenia: A Comparative Study of Neuroleptics

Chronic schizophrenia is a complex mental illness that can significantly impact an individual's life. This study compares the therapeutic efficacy and side effect profiles of two neuroleptics, haloperidol and flupenthixol, in chronic schizophrenic inpatients.

Neuroleptic Effects: A Comparative Analysis

The study found that haloperidol appeared to produce lower levels of psychopathology than flupenthixol, but similar levels of side effects. However, no evidence was found to support the claim that flupenthixol is particularly effective in 'activating' chronic patients or alleviating affective symptoms.

Understanding Neuroleptic Mechanisms: A Focus on Dopamine Receptors

The study's findings suggest that dopamine receptors may mediate the antipsychotic effects of neuroleptic drugs. This understanding could guide the development of more targeted and effective treatment strategies for chronic schizophrenia.

Dr.Camel's Conclusion

The search for effective treatments for chronic schizophrenia is a continuous journey across the vast desert of mental health. This study sheds light on the complex effects of different neuroleptics, emphasizing the need for individualized treatment strategies based on a deeper understanding of the underlying mechanisms of action.

Date :
  1. Date Completed 1987-07-31
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

3298328

DOI: Digital Object Identifier

3298328

SNS
PICO Info
in preparation
Languages

English

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