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Magnesium Citrate Increases Pain Threshold and Reduces TLR4 Concentration in the Brain.

Author: AtesMehmet, GumusHikmet, HosgorlerFerda, KandisSevim, KizildagServet, KocBasar, UysalNazan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A single dose of magnesium citrate was found to reduce pain perception in mice. The study also found that magnesium citrate changes the expression of TLR4, a receptor involved in pain perception, in both the brain and the sciatic nerve. These findings suggest that magnesium citrate may have potential as a treatment for acute pain.
Paper Details　
Original Abstract of the Article :
Magnesium is being investigated in various clinical conditions and has shown to be effective in some chronic pain models. However, it is not clear if oral magnesium use affects pain perception in acute pain. TLR4's (toll-like receptor) role in pain perception has emerged through its role in immune p...See full text at original site
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引用元：
https://doi.org/10.1007/s12011-020-02384-5

データ提供：米国国立医学図書館（NLM）

Magnesium Citrate: A Potential Oasis in the Desert of Pain

Chronic pain is a debilitating condition that affects millions of people worldwide. While various treatments are available, the search for effective and safe pain relief options continues. This study investigates the potential of magnesium citrate, a readily available mineral supplement, in reducing pain perception. The researchers explored the effects of a single oral dose of magnesium citrate on pain sensitivity and the expression of TLR4, a protein involved in pain signaling pathways.

Magnesium Citrate: Easing the Pain in the Desert

The study found that a single dose of magnesium citrate significantly increased pain threshold in mice, suggesting its potential to reduce pain perception. Interestingly, the researchers observed a decrease in TLR4 expression in the brain following magnesium administration, indicating a possible mechanism by which magnesium may exert its pain-relieving effects.

Magnesium: A Potential Ally in the Battle Against Pain

This research offers promising insights into the potential of magnesium citrate as a pain-relieving agent. While further research is needed to confirm these findings in humans, the results suggest that magnesium citrate may play a role in reducing pain sensitivity and inflammation.

Dr.Camel's Conclusion

This research takes us on a journey through the arid landscape of pain management, exploring the potential of magnesium citrate as a natural pain reliever. Like a refreshing oasis in the desert, magnesium citrate may offer a natural and effective way to alleviate pain. While more research is needed, the results suggest that magnesium citrate could be a valuable tool in the fight against pain.

Date :
  1. Date Completed 2021-06-18
  2. Date Revised 2022-05-31
Further Info :

Pubmed ID

32989649

DOI: Digital Object Identifier

10.1007/s12011-020-02384-5

Related Literature

Article Analysis
・Effects of magnesium citrate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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