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The prognostic value of CA19-9 response after neoadjuvant therapy in patients with pancreatic cancer: a systematic review and pooled analysis.

Author: GuoXin, RenSiqian, SadulaAbuduhaibaier, XiuDianrong, YeChen, YuanChunhui, YuanMeng

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study investigates the correlation between Carbohydrate antigen 19-9 (CA19-9) response and overall survival (OS) in patients with pancreatic cancer (PC) receiving neoadjuvant therapy.
Paper Details　
Original Abstract of the Article :
Pancreatic cancer (PC) is a highly aggressive and refractory disease, with disappointing 5-year survival rates. Regarding the wide application of neoadjuvant treatment in patients with PC, how the post-neoadjuvant Carbohydrate antigen 19-9 (CA19-9) response could translate into a survival benefit is...See full text at original site
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引用元：
https://doi.org/10.1007/s00280-020-04165-2

データ提供：米国国立医学図書館（NLM）

CA19-9 Response: A Prognostic Beacon in Pancreatic Cancer

This research journeys into the complex field of oncology, specifically focusing on the prognostic value of CA19-9 response, a tumor marker, in patients with pancreatic cancer who receive neoadjuvant therapy. Pancreatic cancer, a highly aggressive and often deadly disease, is often treated with neoadjuvant therapy, a pre-operative approach aimed at shrinking the tumor before surgery. This study investigated the association between CA19-9 response to neoadjuvant therapy and overall survival in patients with pancreatic cancer. The researchers aimed to determine whether changes in CA19-9 levels after neoadjuvant therapy could predict patient survival, offering valuable insights into the potential of this marker as a prognostic tool.

Decoding the Signals of Pancreatic Cancer

This research delves into the intricate world of tumor markers, exploring their potential as indicators of treatment response and patient outcomes. The study's findings suggest that CA19-9 response to neoadjuvant therapy may hold prognostic value in pancreatic cancer, offering potential insights into the effectiveness of treatment and the likelihood of long-term survival.

Guiding Treatment and Predicting Outcomes

This research underscores the importance of carefully monitoring tumor marker levels throughout the course of pancreatic cancer treatment. The study's findings highlight the potential of CA19-9 response as a prognostic tool, providing valuable information for guiding treatment decisions, tailoring therapy, and predicting patient outcomes. This information can ultimately contribute to improving patient care and potentially enhancing survival rates.

Dr.Camel's Conclusion

This research explores the use of CA19-9, a tumor marker, in predicting how well patients with pancreatic cancer will respond to treatment. They found that changes in CA19-9 levels after pre-operative therapy might be linked to how long patients live. This research suggests that monitoring CA19-9 levels could be helpful in guiding treatment decisions and predicting outcomes for patients with pancreatic cancer.
Date :
  1. Date Completed 2021-05-21
  2. Date Revised 2021-05-21
Further Info :

Pubmed ID

33047181

DOI: Digital Object Identifier

10.1007/s00280-020-04165-2

Related Literature

Article Analysis
・Effective treatment of pancreatic cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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