Effectiveness and safety of high dose clopidogrel plus aspirin in ischemic stroke patients with the single CYP2C19 loss-of-function allele: a randomized trial.

Author: ChenQi, ChuWenzheng, DongMei, DouLianwei, GaoBo, LiBing, LiJiazhen, LiuChuanyu, PanYan, SongHuiqun, SongLixiang, WuHongliang

Paper Details 
Original Abstract of the Article :
Dual antiplatelet aggregation therapy leads to better outcomes in patients with carotid artery stenosis, intracranial artery stenosis, minor strokes, or transient ischaemic attacks. However, carriers of the CYP2C19 loss-of-function allele may not experience the desired effects. We attempted to incre...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596994/

データ提供:米国国立医学図書館(NLM)

High-Dose Clopidogrel: A New Approach for Stroke Patients

Stroke, a devastating event that can leave lasting impacts on individuals, is like a sudden desert storm that disrupts lives. This research, like an expedition seeking to find a solution to this devastating condition, investigates the effectiveness of high-dose clopidogrel combined with aspirin in stroke patients who carry a specific genetic variation (CYP2C19 loss-of-function allele). The authors, like skilled desert navigators, aim to find the right combination of medications to optimize treatment outcomes in these challenging cases.

A Personalized Approach: Tailoring Treatment to Genetic Variations

The authors highlight the importance of considering genetic variations when prescribing medications. This research, like a desert explorer adapting to the changing landscape, recognizes the need to personalize treatment strategies to address the unique needs of individual patients. This study emphasizes the growing role of pharmacogenetics in shaping future healthcare practices, allowing for more precise and effective treatments.

A New Oasis of Hope: High-Dose Clopidogrel's Promise

This research, like a beacon of hope in the desert of stroke recovery, explores the potential of high-dose clopidogrel as a valuable tool in managing stroke patients. The study aims to determine whether increasing the dose of clopidogrel can enhance the benefits of dual antiplatelet therapy in stroke patients who carry the CYP2C19 loss-of-function allele. This research, like a wellspring in the desert, could lead to improved outcomes for stroke patients and their families.

Dr.Camel's Conclusion

This research, a testament to the ongoing quest for better stroke treatments, explores the potential of personalized medicine and pharmacogenetics. The authors' focus on optimizing treatment outcomes for stroke patients with genetic variations underscores the importance of tailoring medical care to individual needs. This study, like a sandstorm that eventually subsides, represents a step forward in the ongoing struggle against stroke and its devastating consequences.

Date :
  1. Date Completed 2021-01-11
  2. Date Revised 2021-01-11
Further Info :

Pubmed ID

33121452

DOI: Digital Object Identifier

PMC7596994

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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