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Real-World Comparison of Elobixibat and Lubiprostone Treatment in Patients with Chronic Constipation: A Propensity Score-Matched Analysis.
Author: AmiokaShohei, EguchiTakaaki, FujinamiMaho, IkeokaSeitaro, InoueKazuki, KatayamaNorio, MatsudaTatsuya, MatsumotoMasanori, MomoseKenji, MorisawaToshiyuki, NodaMari, NonakaTakahiro, OkadaAkihiko, SakoTomoya, TakagiMegumi, YamaguchiTsubasa, YoshizakiTetsuya
Original Abstract of the Article :
INTRODUCTION: Elobixibat is a new laxative, but its efficacy and adverse events (AEs) are insufficiently examined compared with those of other laxatives. Hence, by propensity score (PS) matching, we compared the effects and AEs between elobixibat and lubiprostone. METHODS: We retrospectively analyz...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1159/000512745
データ提供:米国国立医学図書館(NLM)
Elobixibat vs. Lubiprostone: A Real-World Comparison for Chronic Constipation
This research delves into the real-world effectiveness of two medications used to treat chronic constipation, elobixibat and lubiprostone. The study compared the effects of these medications on bowel movements and stool consistency, using a propensity score-matched analysis to account for differences in patient characteristics. The researchers found that both lubiprostone (at both 24 μg and 48 μg doses) were more effective in improving stool consistency compared to elobixibat. However, elobixibat was associated with fewer adverse effects, particularly nausea. This research provides valuable information for healthcare providers and patients to make informed decisions about treatment options for chronic constipation.
Elobixibat: A Safer Option for Mild Constipation
This research reveals that while lubiprostone demonstrated greater effectiveness in improving stool consistency, elobixibat was associated with fewer adverse effects, particularly nausea. This finding suggests that elobixibat may be a more suitable treatment option for patients experiencing mild chronic constipation, where the potential for adverse effects is a key concern.
Navigating the Desert of Constipation
Just as a camel navigates a challenging desert terrain, patients with chronic constipation must find effective ways to manage their condition. This research offers a comprehensive comparison of two medications, elobixibat and lubiprostone, providing valuable insights for healthcare providers and patients to make informed decisions about treatment options. It's like finding a hidden oasis in the desert – this research could lead to a more personalized and effective approach to managing constipation.
Dr.Camel's Conclusion
This research offers a valuable comparison of two medications used to treat chronic constipation. The study's findings highlight the importance of considering both efficacy and safety when making treatment decisions. It's like a camel carefully choosing its path through the desert – understanding the nuances of these medications can lead to a more comfortable and effective treatment experience.
Date :
- Date Completed 2021-07-16
- Date Revised 2021-07-16
Further Info :
Related Literature
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