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Simvastatin ointment in the treatment of seven childhood diffuse plane xanthomas.

Author: GuYan, GuoYifeng, YangLan, YaoZhirong, YuXia, ZhangWenqing, ZhangZhen

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Simvastatin ointment, at both 1% and 5% concentrations, was found to be effective in improving skin lesions in patients with diffuse plane xanthomas (DPX), a rare, chronic, metabolic skin disease. The treatment resulted in a significant decrease of foam cells and reduced immunohistochemical staining of CD68, macrophage scavenger receptor type 1, oxidized low-density lipoprotein receptor 1, and Oil Red O.
Paper Details　
Original Abstract of the Article :
Diffuse plane xanthomas (DPX) is a rare, chronic, metabolic skin disease which can seriously affect the appearance of the patients and result in psychological problems. Existing treatments are seriously limited. Our objective was to assess the efficacy of and tolerance to simvastatin ointment for th...See full text at original site
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引用元：
https://doi.org/10.1111/1346-8138.15649

データ提供：米国国立医学図書館（NLM）

Simvastatin Ointment: A Potential Treatment for Diffuse Plane Xanthomas

This study investigates the [efficacy] and [tolerability] of [simvastatin ointment] in the treatment of [diffuse plane xanthomas] (DPX), a rare skin condition. The researchers conducted a [clinical trial] on [seven DPX patients] and found that [simvastatin ointment] significantly reduced [skin lesions] and improved [histological findings]. They conclude that [simvastatin ointment] shows promise as a [treatment option] for [DPX], warranting further investigation.

A New Path in the Desert of Skin Conditions: Simvastatin Ointment for Diffuse Plane Xanthomas

The study sheds light on a potential new treatment for diffuse plane xanthomas, a rare and often challenging skin condition. The findings suggest that simvastatin ointment could be an effective and well-tolerated treatment option, offering hope for individuals struggling with this condition.

Navigating the Shifting Sands of Skin Health

Skin conditions can be like shifting sands, constantly changing and presenting unique challenges. This study offers a glimmer of hope for individuals with diffuse plane xanthomas, suggesting that simvastatin ointment could be a valuable tool for managing this condition. It emphasizes the importance of continued research to explore new and effective treatments for rare skin diseases.

Dr.Camel's Conclusion

This research explores the promising potential of simvastatin ointment as a treatment for diffuse plane xanthomas. The findings suggest that this topical medication could be a valuable option for managing this rare skin condition. Further research is needed to fully understand its efficacy and establish its place in the therapeutic arsenal for DPX patients.
Date :
  1. Date Completed 2021-05-14
  2. Date Revised 2021-05-14
Further Info :

Pubmed ID

33180983

DOI: Digital Object Identifier

10.1111/1346-8138.15649

Related Literature

Article Analysis
・Side Effects of simvastatin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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