Paper Details

  1. Home
  2. Paper Details

Influence of everolimus-based treatment on circulating regulatory T cells after liver transplantation: Comparative study with tacrolimus-based therapy.

Author: AoudjehaneLynda, BarjonClément, ContiFilomena, DahlqvistGéraldine, DurandFrançois, DuvouxChristophe, GhazalKhaldoun, SalibaFaouzi

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Everolimus, an mTOR inhibitor, may be beneficial for liver transplant patients, as it has been shown to promote natural regulatory T cells (Tregs), which are crucial for achieving tolerance and reducing immunosuppressive regimen needs.
Paper Details　
Original Abstract of the Article :
Liver transplantation remains the only treatment for terminal liver diseases. However, immunosuppressive drugs required for allograft acceptance are toxic and may be responsible for severe side effects. Modulating the immune system to induce tolerance is a promising approach to reduce immunosuppress...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.clinre.2020.10.004

データ提供：米国国立医学図書館（NLM）

Everolimus: A Potential Game-Changer in Liver Transplantation

Liver transplantation is a life-saving procedure, but the immunosuppressive drugs required to prevent rejection can have severe side effects. This study compares the influence of everolimus-based treatment with tacrolimus-based therapy on circulating regulatory T cells (Tregs) in liver transplant recipients. The authors found that everolimus, an mTOR inhibitor, may have a positive impact on Tregs levels compared to tacrolimus, a calcineurin inhibitor, suggesting that everolimus could potentially contribute to inducing tolerance and reducing the need for immunosuppressive drugs.

Everolimus: A Potential Boon for Tregs in Liver Transplantation

This study provides intriguing evidence of the potential benefits of everolimus-based treatment in liver transplantation. The findings suggest that everolimus may have a positive impact on Tregs levels, potentially promoting tolerance and reducing the need for immunosuppressive drugs, which could lead to fewer side effects and improved long-term outcomes for transplant recipients.

Liver Transplantation: Towards a New Era of Tolerance

This research explores the potential of everolimus as a promising agent in liver transplantation. The study's findings suggest that everolimus may contribute to inducing tolerance by promoting Tregs, potentially leading to a reduction in immunosuppressive drug use and a better overall outcome for transplant recipients. This research offers a glimmer of hope for a future where transplantation is a safer and more effective treatment option for liver diseases.

Dr.Camel's Conclusion

This research, like a desert traveler discovering a hidden spring, reveals the potential of everolimus in influencing Tregs and promoting tolerance in liver transplantation. The findings suggest that everolimus could potentially pave the way for a future where transplantation is a less invasive and more effective treatment option for liver diseases, offering a new path to better health and well-being for those in need.

Date :
  1. Date Completed 2022-03-01
  2. Date Revised 2022-03-01
Further Info :

Pubmed ID

33191181

DOI: Digital Object Identifier

10.1016/j.clinre.2020.10.004

Related Literature

Article Analysis
・Side Effects of everolimus
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.